SPONTANEOUS TUMORS IN F344/DuCrj RATS FROM 12 CONTROL GROUPS OF CHRONIC AND ONCOGENICITY STUDIES
スポンサーリンク
概要
- 論文の詳細を見る
The types and incidences of spontaneous tumors in F344/DuCrj rats were examined in 960 males and 959 females served as the control groups of separate twelve 2-year chronic and oncogenicity studies carried out during a 1978-1983 period. The major tumors occurred at more than 5% incidence were leukemia (mononuclear cell), testicular interstitial cell tumor, preputial gland adenoma, pituitary anterior adenoma, thyroid C-cell adenoma, adrenal pheochromocytoma and subcutis fibroma for males, and leukemia, uterine endometrial polyp, pituitary anterior adenoma, thyroid C-cell adenoma and mammary gland adenoma/fibroadenoma in females. Analyses on age-related occurrence of tumors revealed that the incidences of most of the major tumors in males attained already to the plateau between 85 and 97 weeks of age while those in females showed a steep rise during the last interval of observation, 98 to 110 weeks of age. An intralaboratory heterogeneity in incidence was observed in the thyroid C-cell adenoma and the adrenal pheochromocytoma for males, and the anterior pituitary adenoma for females.
- 日本トキシコロジー学会の論文
- 1987-05-25
著者
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Hirano Masahiro
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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Kosaka Tadashi
The Institute of Environmental Toxicology
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Enomoto Akiko
The Institute of Environmental Toxicology
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Nakashima Nobuaki
The Institute of Environmental Toxicology
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Harada Takanori
The Institute of Environmental Toxicology
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Mitsumori Kunitoshi
杏林製薬研究センター
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Yoshida Akiyoshi
Toxicology Division Mitsukaido Laboratories The Institute Of Environmental Toxicology
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Yoshida Akiyoshi
残留農薬研究所
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Inui Kosei
Central Research Institute Ishihara Sangyo Kaisha Ltd.
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Inui Kosei
残留農薬研究所
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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Maita Keizo
Toxicology Div. Inst. Environmental Toxicology
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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HARADA Takanori
Toxicology Division, Institute of Environmental Toxicology
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TAKAHASHI Kimimasa
Toxicology Division, Institute of Environmental Toxicology
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NAKASHIMA Nobuaki
Toxicology Division, Institute of Environmental Toxicology
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KITAZAWA Toshiaki
Toxicology Division, Institute of Environmental Toxicology
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ENOMOTO Akiko
Toxicology Division, Institute of Environmental Toxicology
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INUI Kosei
Toxicology Division, Institute of Environmental Toxicology
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SHIRASU Yasuhiko
Toxicology Division, Institute of Environmental Toxicology
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TAKAHASHI Kazuaki
Institute of Environmental Toxicology
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SHIRASU Yasuhiko
Institute of Environmental Toxicology
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Kosaka T
Toxicology Division Institute Of Environmental Toxicology
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Hirano Masahiro
Electrotechnical Laboratory
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Shirasu Y
Inst. Environmental Toxicology Ibaraki Jpn
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Kosaka T
Inst. Environmental Toxicology Tokyo Jpn
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Yoshida Akiko
Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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Shirasu Yasuhiko
Toxicology Division Institute Of Environmental Toxicology
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Hirano Masahiro
Electrotechnical Laboratory:optoelectronics Joint Research Laboratory
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Nakashima Nobuaki
Toxicology Division Institute Of Environmental Toxicology
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Harada Takanori
Toxicol. Div. The Inst. Environ. Toxicol.
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Kitazawa Toshiaki
Toxicology Division Institute Of Environmental Toxicology
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Takahashi Kazuaki
Institute Of Environmental Toxicology:(present Address)nippon Veterinary & Zootechnical College
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Inui Kosei
Toxicology Division Institute Of Environmental Toxicology
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