INHIBITORY EFFECTS OF REPEATED INTRAVENOUS INJECTIONS OF DEXAMETHASONE ON PULMONARY TOXICITY OF A NEW MITOMYCIN C ANALOGUE, KW-2149, IN A NOVEL RAT MODEL
スポンサーリンク
概要
- 論文の詳細を見る
An animal model for testing pulmonary toxicity of KW-2149, a new mitomycin C analogue, was developed(by intravenously injecting 3.28 mg / kg of the drug in to male SD rats 3 times at weekly intervals), and exhibits pleural effusion from 1 week after the last injection. In this animal model, repeated intravenous injections of dexamethasone(DM), following any of three different schedules examined, were more or less effective of reducing the amount of effusion. The optimal results were obtained with 4 administrations a week(i. e. twice before and twice after KW-2149 treatment). The results of the present experiment suggest possible clinical application of DM in protecting patients from pulmonary toxicity of KW-2149.
- 日本トキシコロジー学会の論文
- 2000-02-28
著者
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Tamura T
Division Of Internal Medicine National Cancer Center Hospital
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Harada Takanori
The Institute of Environmental Toxicology
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Saijo N
Division Of Internal Medicine National Cancer Center Hospital East
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Saijo Nagahiro
国立医薬品食品衛生研究所
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Saijo N
Medical Oncology National Cancer Center Hospital
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SAIJO Nagahiro
National Cancer Center Hospital East
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Yamamoto Noboru
国立医薬品食品衛生研究所
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Yamamoto N
Thoracic Oncology Division National Cancer Center Hospital National Cancer Center
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Tamura Tomohide
国立がんセンター中央病院 腫瘍内科
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Tamura T
National Cancer Center Hospital Tokyo
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Tamura Tomohide
Medical Oncology Division National Cancer Center Hospital
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Tagawa Toshiaki
国立がんセンター中央病院 消化器内科
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Takaba Katsumi
協和醗酵工業
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Takaba Katsumi
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Takaba Katsumi
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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石井 昭男
協和発酵医薬研
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TAMURA Tomohide
National Cancer Center Hospital
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Saijo Nagahiro
Department Of Internal Medicine National Cancer Center Hospital
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Saijo Nagahiro
National Cancer Center
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Kodama Tetsuro
Division Of Thoracic Oncology And Internal Medicine National Cancer Center Hospital
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Takaba K
Kyowa Hakko Kogyo Co. Ltd. Yamaguchi Jpn
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HARA Takuji
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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ISHII Akio
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Tamura Tomohide
Division Of Internal Medicine National Cancer Center Hospital
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Tamura Tomohide
National Cancer Center
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ISHII AKIO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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YAMAMOTO Noboru
National Cancer Center Hospital
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Ishii A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Ishii Akio
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Hara Takuji
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd
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Yamamoto Nobuko
Department Of Internal Medicine National Cancer Center Hospital
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Yamamoto N
College Of General Education Kyoto University
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石井 昭男
協和発酵工業(株)医薬研究所
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ISHII Akio
Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
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