MECHANISM OF FK506-INDUCED GLUCOSE INTOLERANCE IN RATS
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概要
- 論文の詳細を見る
To clarify the mechanism of glucose intolerance induced by FK506, a novel immunosuppressant, 5 or 10 mg/kg/day of FK506 was dosed orally to rats for 2 weeks, and ^<125>I-insulin binding to the erythrocytes, plasma glucose and insulin levels, and pancreatic insulin content were examined. Insulin binding to the erythrocytes of rat dosed with FK506 was similar to that to erythrocytes of the placebo control; Scatchard analysis confirmed that FK506 did not cause damage to the insulin receptor of the erythrocytes. Contrarily, FK506 caused a clear decrease of pancreatic insulin content as well as a slight decrease of plasma insulin level. The results suggest that the glucose intolerance induced by FK506 is associated with a decrease of insulin secretion, but is not associated with impairment of the insulin receptor.
- 日本トキシコロジー学会の論文
- 1994-05-25
著者
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OHARA Kaname
Toxicol. Res. Lab., Fujisawa Pharmaceutical Co., LTD.
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Tamura T
Division Of Internal Medicine National Cancer Center Hospital
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Tamura Tomohide
国立がんセンター中央病院 腫瘍内科
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Tamura T
National Cancer Center Hospital Tokyo
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Tamura Tomohide
Medical Oncology Division National Cancer Center Hospital
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Tagawa Toshiaki
国立がんセンター中央病院 消化器内科
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Ohara K
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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MITAMURA Takashi
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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NOGUCHI Hideyo
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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MINE Yasuhiro
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Tamura Tomohide
Division Of Internal Medicine National Cancer Center Hospital
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HIRANO Yuri
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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TAMURA Takayuki
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Hirano Yuri
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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MITAMURA Takashi
Advanced Science Research Laboratory, Saitama Institute of Tehnology
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Mine Y
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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Mine Yasuhiro
Toxicicology Research Laboratories Fujisawa Pharmaceutical Co.ltd.
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Mitamura Takashi
Drug Safety Res. Laboratories Astellas Pharma Inc.
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Mitamura Takashi
Drug Safety Research Laboratories Astellas Pharma Inc.
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Noguchi H
Daiich Pure Chemicals Co. Ltd. Tokyo Jpn
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Noguchi Hideyo
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tamura Takayuki
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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