Time-Course Change of Testicular Toxicity with Thiamphenicol in Male Sprague-Dawley Rats
スポンサーリンク
概要
- 論文の詳細を見る
A total of 30 male Sprague-Dawley rats were treated orally with thiamphenicol (TAP) at 200 mg/kg/day for up to 4 weeks followed by 10 weeks recovery. At each week of treatment, 5 of them were examined weights of the testis and accessory genital glands, histology, staging analysis, and measurements of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone (TES). At weeks 3 and 10 of recovery, 5 of them were quantified sperm counts and motility in addition to examinations of organ weights and histology. Cell proliferation activity was assessed at week 10 of recovery. Another group of 10 animals was provided as the vehicle control and examined the same parameters as mentioned above at week 4 of treatment or at week 10 of recovery. Weights of the seminal vesicles and prostate were significantly decreased during the treatment but showed a remarkable recovery after cessation of dosing. The testicular weights decreased rather mildly during the treatment but kept decreasing during the recovery period. In histology, damage of germ cells included apoptosis of germ cells, frequent occurrence of giant cells, and vacuolar spaces in the seminiferous tubules. In staging analysis, the first decreased indices were observed in spermatogonia (type B spermatogonia) in stage V and preleptotene spermatocytes in stage VII at week 2 of treatment. During recovery, an intact seminiferous tubule was seen neighboring to the other one showing “Sertoli only syndrome”. Cell proliferation activity was preserved in isolated cells on the basement membrane of “Sertoli only syndrome” seminiferous tubules. Considerable recovery was observed in sperm counts and motility. Serum TES and LH were decreased at week 4 of treatment but no effects on FSH. It is most likely that Sertoli cells are the primary target in TAP toxicity.
- 日本毒性病理学会の論文
- 2003-03-30
著者
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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Kosaka Tadashi
The Institute of Environmental Toxicology
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Harada Takanori
The Institute of Environmental Toxicology
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Mitsumori Kunitoshi
杏林製薬研究センター
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Maita Keizo
The Institute of Environmental Toxicology
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Kuwahara Maki
The Institute of Environmental Toxicology
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Inui Kosei
Central Research Institute Ishihara Sangyo Kaisha Ltd.
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Inui Kosei
残留農薬研究所
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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Kuwahara M
Inst. Environmental Toxicology Ibaraki Jpn
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Kuwahara Maki
Laboratory Of Pathology Toxicology Division Chemistry Division Institute Of Environmental Toxicology
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Harada Tomoko
協和醗酵工業
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Harada Tomoko
Toxicological Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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TAKAHASHI Kazuaki
Institute of Environmental Toxicology
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原田 孝則
The Institute of Environmental Toxicology
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Kosaka T
Toxicology Division Institute Of Environmental Toxicology
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TAKAHASHI Naofumi
The Institute of Environmental Toxicology
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SUGIMOTO Kayoko
Formerly, The Institute of Environmental Toxicology
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KASHIMOTO Yukiko
The Institute of Environmental Toxicology
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SUGIMOTO Kayoko
Pathology Laboratory, Nippon Institute for Biological Science
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TAKAHASI Naofumi
The Institute of Environmental Toxicology
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Sugimoto Kayoko
Formerly The Institute Of Environmental Toxicology
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Kosaka T
Inst. Environmental Toxicology Tokyo Jpn
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Tanaka Naoki
Laboratory Of Animal Management And Testing Chemistry Division Institute Of Environmental Toxicology
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Takahashi Kazuaki
Institute Of Environmental Toxicology:(present Address)nippon Veterinary & Zootechnical College
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Takahashi N
The Institute Of Environmental Toxicology
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