Preventive Effects of Shinchimotsu-koka-to on Renal Lesions in Stroke-Prone Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
Shichimotsu-koka-to (SKT) has been prescribed to treat patients with essential and renal hypertension. We investigated the effects of SKT on renal lesions in stroke-prone spontaneously hypertensive rats (SHRSPs). SHRSPs were gievn an extarct of SKT by mixing it with drinking water, from 8 through 29 weeks of age, so that the average intake of SKT extract was about 1.5 g/kg/d. At 29 weekd of age, the kidneys of SHRSPs exhibited proliferative arteritis characterized by the proliferation of smooth muscle cells in the interloubular arteries, dilation and degeneration of renal tubules, infiltration of inflammatory cells and hemorrhage, with partial swelling or necrotizing of glomeruli. In particular, arteritis and periarteritis were noted. The treatment of SHRSPs with SKT ameliorated this morphological damage in the kidney and significantly decreased urea nitrogen in the serum. Treatment with SKT also strongly decreased the xanthine oxidase (XOD) activity and significantly increased the superoxide dismutase (SOD) activity in the kidney of SHRSPs; consequently, these values became close to those in normotensive Wistar Kyoto rats (WKYs). These results indicate that treatment with SKT ameliorated the histopathological damage and change in activity of enzymes related to free radicals in the kidney of SHRSPs, which may be important mechanisms for SKT for protecting SHRSPs from renal dysfunction.
- 公益社団法人日本薬学会の論文
- 1998-09-15
著者
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Nara Yasuo
Department Of Pharmacy School Of Pharmacy Shujitsu University
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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ONODERA Hiroshi
Division of Pathology, National Institute of Health Sciences
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MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
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Mitsumori Kunitoshi
杏林製薬研究センター
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Onodera Hiroshi
東京都健康安全研究センター
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Onodera Hiroshi
Pharmaceuticals And Medical Devices Agency
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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SATAKE Motoyoshi
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
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Satake M
Institute Of Environmental Science For Human Life Ochanomizu University
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Sekita Setsuko
大阪府立公衆衛生研究所
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Sekita Setsuko
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Sekita Setsuko
National Institute Of Health Sciences
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ONO Kageyoshi
Division of Xenobiotic Metabolism Disposition, National Institute of Health Sciences
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Satake Motoyoshi
Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences
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Satake Motoyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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HIGUCHI Yukito
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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Higuchi Yukito
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Higuchi Yukito
Shimonoseki Junior College
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Onodera H
Pharmaceuticals And Medical Devices Agency
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三森 国敏
Division Of Pathology National Institute Of Health Sciences
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Sekita Setsuko
湧永製薬ヘルスケア研究所
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Nara Yasuo
Department Of Nutrition Science Division Of Applied Life Sciences Graduate School Of Integrated Scie
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Ono Kageyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Onodera H
Division Of Pathology National Institute Of Health Sciences
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Higuchi Y
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Satake Motoyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Science
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Ono Kageyoshi
Division Of Xenobiotic Metabolism And Disposition National Institute Of Health Siences
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Satake Motoyoshi
Division Of Pharmacognosy And Phyochemistry National Institute Of Health Sciences
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Nara Yasuo
Department of Medicine, SANRAKU Hospital
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