Prevalence of Autoantibody in Cerebrospinal Fluids from Dogs with Various CNS Diseases
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概要
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To examine the prevalence of autoantibody in canine cerebrospinal fluids (CSFs), CSFs were collected from 14 healthy controls and 88 clinical cases with various diseases in the central nervous system (CNS), and were analyzed by an indirect fluorescence antibody test on frozen sections of the cerebrum from normal Beagle dogs. An anti-astrocyte autoantibody was detected in 31 clinical cases with titers ranging from 1:1 to ≥1:100. All tested cases with necrotizing meningoencephalitis (NME: n=22) and granulomatous meningoencephalitis (GME: n=3) possessed the anti-astrocyte autoantibody, while the autoantibody was negative in most cases with other inflammatory CNS diseases. The autoantibody was also detected in 4 of 12 cases with brain tumors. Hence, examination of the autoantibody in the canine CFS would be significant for diagnosing NME and/or GME, as well as for understanding peritumoral events in cases with brain tumors.
著者
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TAMAHARA Satoshi
Departments of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences,
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Nakayama Hiroyuki
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Doi Kunio
Department Of Applied Chemistry Nagoya Institute Of Technology
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Ono Kenichiro
Department Of Neurosurgery Japan Self Defense Forces Central Hospital:(present Office)division Surge
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Matsuki Naoaki
Department Of Veterinary Clinical Pathobiology Graduate School Of Agriculture And Life Sciences The
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Matsunaga Satoru
Department Of Anatomy Tokyo Dental College
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Uchida Kazuyuki
Department Of Veterinary Pathology Graduated School Of Agricultural And Life Sciences The University
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Ogawa Hiroyuki
Department Of Aerospace Engineering Nagoya University
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Fujiwara Kaori
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan
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MATSUNAGA Satoru
Department of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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TAMAHARA Satoshi
Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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