Comparison of Age-Related Bone Changes between Mini Rats and Wistar Rats
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that in Mini rats, rats of transgenic Jcl: Wistar-TgN (ARGHGEN) 1Nts strain, the expression of rat growth hormone (GH) gene was suppressed by the presence of an antisense transgene, resulting in lowered plasma GH levels compared with nontransgenic Wistar rats. GH is thought to have an important role in bone growth, but bone changes of Mini rats have not been reported. In the present study, we examined the femurs of both male Mini rats and male Wistar rats at different ages, i.e. 8 and 22 weeks of age, and compared them between both rat strains. As a result, Mini rats showed smaller sizes of the femur with low mineral densities histologically characterized by the metaphyseal and diaphyseal bone be a possible animal model for osteopenia.
- 日本毒性病理学会の論文
- 1998-06-01
著者
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真鍋 淳
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd
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寺西 宗広
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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真鍋 淳
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Tani Yoshiro
東京大学 農学生命科研究科
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谷 吉朗
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Tani Yoshiro
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Tani Yoshiro
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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寺西 宗広
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
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Teranishi Munehiro
Medicinal Safety Res. Laboratories Daiichi-sankyo Co. Ltd.
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谷 吉朗
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Manabe Sunao
Medicinal Safety Laboratories Daiichi Sankyo Co. Ltd.
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Manabe Sunao
Medical Safety Research Laboratories Sankyo Co. Ltd.
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Manabe Sunao
Med.safe.res.labs. Sankyo Co. Ltd. Of Shizuoka Pref.
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寺西 宗広
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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寺西 宗広
Medicinal Safety Research Labs Sankyo Co. Ltd.
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寺西 宗広
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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谷 吉朗
三共
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Teranishi Munehiro
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
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MANABE Sunao
Medicinal Safety Laboratories, Daiichi Sankyo Co., Ltd.
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