PRELIMINARY DOSE FINDING STUDY FOR SUBACUTE TOXICOLOGICAL STUDY OF PRAVASTATIN SODIUM IN MONKEYS
スポンサーリンク
概要
- 論文の詳細を見る
Pravastatin sodium was orally administered to cynomolgus monkeys at dosage levels of 50, 200 and 800 mg/kg/day for 7 successive days. Excretions of diarrhea and/or loose stool were observed in the more than 50 mg/kg dose group, but the changes were quite mild. Animals of the 800 mg/kg dose group showed vomiting, diarrhed and/or excretion of soft stool and reduction of cholesterol content in serum. In conclusion, it is estimated that the no effective level is less than 200 mg/kg because no abnormalities were observed except for only very slight excretions of diarrhea and/or loose stool, and that the effective dose is 800 mg/kg in which vomiting was observed.
- 日本トキシコロジー学会の論文
- 1989-08-20
著者
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MANABE Sunao
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
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Yamashita Kazuo
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd.
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山下 和男
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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MASUDA Hiroshi
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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Manabe Sunao
Medicinal Safety Laboratories Daiichi Sankyo Co. Ltd.
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Masuda Hiroshi
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
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Masuda H
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Yamashita Kazuo
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
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Matsunuma Naochika
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Matsunuma Naochica
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Manabe S
Medical Safety Research Laboratories Sankyo Co. Ltd.
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Yamashita K
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
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MIYAKOSHI Nobuhiro
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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SUDO Seiji
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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Sudo Seiji
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Matsunuma Naochika
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co Ltd.
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Manabe Sunao
Medicinal Safety Research Labs. Daiichi Sankyo Co. Ltd.
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Masuda H
Department Of Biosciences And Technology Faculty Of Agriculture Iwate University
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Miyakoshi N
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
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Matsunuma Naochika
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
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Masuda Hiroshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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MANABE Sunao
Medicinal Safety Laboratories, Daiichi Sankyo Co., Ltd.
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