LONG TERM ORAL ADMINISTRATION STUDY OF PRAVASTATIN SODIUM TO BEAGLES FOR 104 WEEKS
スポンサーリンク
概要
- 論文の詳細を見る
Pravastatin sodium was successively given for 104 weeks to beagles orally at doses of 5 and 25mg/kg/day. A decrease in serum cholesterol levels was observed at week 4 and thereafter. No other abnormal findings were obtained in any animals in general conditions, hematological and biochemical examinationd, various function tests, and pathological examinations. The no-effect dose level in beagles receiving pravastatin sbdium orally for 104 weeks is toxicologically estimated to be more than 25mg/kg/day.
- 日本トキシコロジー学会の論文
- 1989-08-20
著者
-
Yamashita Kazuo
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd.
-
山下 和男
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
TARUMI Chitoshi
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
MASUDA Hiroshi
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
Masuda Hiroshi
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
-
Masuda H
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
-
MATSUNUMA Naochika
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
Yamashita Kazuo
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
-
Matsunuma Naochika
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Matsunuma Naochica
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Matsunuma Naochika
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Yamashita K
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
-
MIYAKOSHI Nobuhiro
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
Matsunuma Naochika
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co Ltd.
-
Tarumi Chitoshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Tarumi Chitoshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd
-
Masuda H
Department Of Biosciences And Technology Faculty Of Agriculture Iwate University
-
Miyakoshi N
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
-
Matsunuma Naochika
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
-
Masuda Hiroshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
関連論文
- Effect of Glucose Feeding on Regenerating Rat Liver Following Partial Hepatectomy
- "P-36 Hepatic response to continuous cytochrome P450 inhibition in rats sequentially treated with α-hederin.
- DOES GLUCOSE FEEDING POTENTIATE THE TOXICITY OF HEPATOTOXICANTS?
- Cooperative Effect of Activated Charcoal and Gellan Gum on Grape Protoplast Culture(Biological Chemistry)
- Mechanism for the Formation of 2,3-Butanediol Stereoisomers in Bacillus polymyxa
- Mechanism for the Formation of 2,3-Butanediol Stereoisomers in Klebsiella pneumoniae
- Laboratory-Scale Production of Acetoin Isomers (D(-) and L(+)) by Bacterial Fermentation
- Stereopecific and Electrophoretic Natures of Bacterial 2,3-Butanediol Dehydrogenases
- Laboratory-Scale Production of 2,3-Butanediol Isomers (D(-), L(+), and Meso) by Bacterial Fermentations
- EFFECT OF DIFFERENT DOSES OF β-NAPHTHOFLAVONE(BNF) ON THE LOCALIZATION OF CYTOCHROME P-450 ISOZYMES IN THE LIVER LOBULE OF RATS
- 323 AN IMMUNOHISTOCHENICAL STUDY ON THE LOCALIZATIONS OF CHEMICAL-INDUCIBLE CYTOCHRONE P-450 WITHIN THE RAT LIVER
- 102 AGE-RELATED CHANGES IN THE SUSCEPTIBILITY OF MALE F344 RAT LIVER TO PEROXISOME PROLIFERATOR, CLOFIBRIC ACID
- 235 COMPARATIVE STUDY OF HEMOLYTIC ANEMIA INDUCED BY ACETYLPHENYLHYDRAZINE IN SIX KINDS OF ANIMALS : RATS, MARMOSETS, MONKEYS, CATS, DOGS AND GOATS
- Simple Isolation Technique for Osteoclasts from Medullary Bones
- Study on the Mechanism of the Antirachitic Effects of T_3
- Ameliorating Effects of Thyroid Hormone on Rickets Induced by a New Rachitogenic Diet
- Effects of Iodine and Thyroid Hormone in Ameliorating Rickets on SteenBock Diet
- CATALASE ACTIVITY OF ERYTHROCYTES FROM BEAGLE DOGS: AN APPEARANCE OF HEREDITARY ACATALASEMIA
- Rapid and Frequent Somatic Embryogenesis from Single Cells of Regenerated Carrot Plantlets
- Effect of in vivo Administration of Thyroid Hormone on Phosphate Uptake of Brush Border Membrane Vesicles from Kidney Cortex of Rachitic Rats
- APPLICATION OF REPEATED BLOOD COLLECTION TECHNIQUE FROM A TAIL VEIN TO TOXICOKINETIC STUDIES IN THE RAT TREATED ORALLY WITH PHENOBARBITAL
- INFLUENCE OF FEEDING CONDITION ON THE ORAL ACUTE TOXICITY OF DRUG IN RATS
- Purification and Properties of NADPH-linked Diacetyl Reductase (S-Acetoin Forming) from Bacillus polymyxa
- A Short-step Synthesis of Theaspirane
- Isolation and Structures of AK-Toxin I and II, Host-specific Phytotoxic Metabolites Produced by Alternaria alternata Japanese Pear Pathotype
- SPECIES DIFFERENCE IN SUSCEPTIBILITY TO PHORBOL MYRISTATE ACETATE-INDUCED LEUKOPENIA AND LUNG INJURY : RAT VS. DOG
- 309 EFFECT OF CLOFIBRATE ON LIVER PEROXISOMES IN SEVERAL RAT STRAINS
- MALE REPRODUCTIVE TOXICITY STUDY OF NITRAZEPAM IN RATS (<SPECIAL ISSUE>TESTICULAR TOXICITY)
- Gene expression analysis on rat livers treated with L-buthionine (S, R)-sulfoximine : investigation of data compatibility between RG U34A and RAE 230A GeneChips(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Gene expression analysis in rat livers and immune organs treated with isoniazid, phenytoin, hydralazine hydrochloride or chlorpromazine(Proceedings of the 32nd Annual Meeting)
- P6-47 Relationship between hepatic glutathione content and gene expression profile in F344 male rats treated with L-Buthionine(S,R)-sulfoximine(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A11 Hepatic foamy cell in Fischer 344 rats : Its age-related morphological properties.
- Isolation of Osteoclast and its Histochemacal Identification
- Significance of carbonic anhydrase on the repair process after bone fracture
- SERIAL OBSERVATION OF CARROT SOMATIC EMBRYOGENESIS AT EARLY STAGE BY VTR
- 322 RELATION BETWEEN CYTOCHRONE P-450 FAMILIES AND THE INDUCTION PROFILE OF 7-ALKOXYCOUMARIN O-DEALKYLASE ACTIVITIES IN RAT LIVER BY SEVERAL CHEMICALS
- Effects of Growth Hormone-Releasing Hormone (GRF) Analogs, Bovine and Rat GRF on Growth Hormone Secretion in Cattle In Vivo
- PEPTIDE-BTNDTNG ASSESSMENT USING MASS SPECTROMETRY AS A NEW SCREENING METHOD FOR SKIN SENSITIZATION
- 321 HEMATOLOGICAL AND SERUM BIOCHEMICAL CHANGES IN DOGS AFTER PARTIAL HEPATECTOMY
- 215 CORRELATION BETWEEN PERIPORTAL NECROSIS AND INDUCTION OF MICROSOMAL ENZYMES AFTER REPEATED ADMINISTRATION OF BUTYLATED HYDROXYTOLUENE(BHT)
- LONG TERM ORAL ADMINISTRATION STUDY OF PRAVASTATIN SODIUM TO BEAGLES FOR 104 WEEKS
- SUBACUTE TOXICOLOGICAL STUDY IN MONKEYS TREATED ORALLY WITH PLAVASTATIN SODIUM FOR 5 WEEKS
- PRELIMINARY DOSE FINDING STUDY FOR SUBACUTE TOXICOLOGICAL STUDY OF PRAVASTATIN SODIUM IN MONKEYS
- 324 EFFECTS OF PHENOBARBITAL(PB) AND PARTIAL HEPATECTOMY(PH) ON HEPATIC MICROSOMAL DRUG METABOLIZING ENZYMES IN BEAGLE DOGS
- S1-3 The diurnal changes of unconditioned behaviors and the behavioral toxicology in the beagle
- Detection of 25-kDa Anti-Agglutinin in Epididymal Plasma and Spermatozoa Collected from Various Regions of Boar Epididymis
- 甜菜サッカラーゼ,とくに結合型サッカラーゼの存在について
- Lectin-Binding Characteristics of Extracts from Epididymal Boar Spermatozoa
- B-18 ANTITHYROID EFFECT OF 3-AMINO-1,2,4-TRIAZOLE AND ITS RELATED COMPOUNDS
- 発芽時甜菜の胚軸と根の遊離型サッカラーゼの部分精製と性質について
- ARTIFACTS IN THE PREPARATION OF HISTOPATHOLOGICAL SPECIMENS (III. Histopathologic diagnosis in toxicity study)
- Hormone-Autonomous Suspension Culture from Leaf Explants of Sugar Beets in Liquid Medium
- Tissue and Organ Expression of Catalase in Acatalasemic Beagle Dogs
- 甜菜主根の発育にともなうヌクレオチド類の消長,特にシヨ糖の生合成に関して
- 3Ba04 テンサイ培養細胞の細胞壁蛋白質について
- 2B-6 発芽初期甜菜結合型サッカラーゼを不活化する物質について
- 3C-7 発芽時甜菜の細胞壁結合型サッカラーゼの性質と細胞壁構成多糖類との結合について
- Duration of Treatment of Carrot Hypocotyl Explants with 2,4-Dichlorophenoxyacetic Acid for Direct Somatic Embryogenesis
- Observation of Early Stage of Somatic Embryogenesis from Epidermal Cells of Carrot Hypocotyls by Scanning Electron Microscopy
- INFLUENCE OF HMG-COA REDUCTASE INHIBITORS ON PLAQUE-FORMING CELL (PFC) RESPONSE IN MICE
- Extraction of Enzymes from Cell Walls of Sugar Beet Cells Grown in Suspension Culture
- Gel chromatographic behavior of pectic substances of sugar beet seedling cell walls in salt solutions of various concentrations
- β-Galactosidase from Cultured Cells of Sugar Beet(Biological Chemistry)
- EFFECTS OF SOME PROTEINS ON EARLY MORPHOGENESIS OF CARROT SOMATIC EMBRYOS
- Somatic embryogenesis of regenerated carrot plantlets
- OCCURRENCE OF FIBRONECTIN-LIKE PROTEIN IN SUSPENSION CULTURE OF CARROT
- Adhesion of expanding cells to cells in carrot embryogenesis
- 日本におけるサケ孵化放流事業の経済効果に関する研究〔英文〕
- Purification of Soluble Acid Invertase from the Mesocarp of Developing Muskmelon (Cucumis melo L. cv. Prince) Fruit(Biological Chemistry)
- Difficult Cases that Require Special Considerations(Part 2)
- CONDITIONS AND PROCESSES OFDIFFERENTIATION OF CARROT SOMATIC EMBRYOGENESIS