PEPTIDE-BTNDTNG ASSESSMENT USING MASS SPECTROMETRY AS A NEW SCREENING METHOD FOR SKIN SENSITIZATION
スポンサーリンク
概要
- 論文の詳細を見る
Skin sensitization potential of low molecular weight chemicals was assessed by analyzing peptide-conjugate formation. Chemicals were incubated with a peptide, glutathione, and resultant mixtures were analyzed by mass spectrometry. Eighteen chemicals were assessed, and new peaks corresponding to chemical-peptide conjugates were detected for 13 of 14 known sensitizers. Conjugates were not detected for 4 negative chemicals. The method has advantages as a simple screening assay for assessing the sensitization potential of chemicals.
- 日本トキシコロジー学会の論文
- 2003-02-28
著者
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FUKUMORI YOSHIHIRO
Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology
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山下 和男
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Kaneko Hideo
Department Of Pediatrics Graduate School Of Medicine Gifu University
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Kaneko H
The Society Of Non-traditional Technology
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Kaneko Hideo
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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NAKAMURA Yosuke
Environ. Health Sci. Lab., Sumitomo Chemical Co., Ltd.
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Kaneko H
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Yamashita Kazuo
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
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Nakamura Yosuke
Environmental Health Scince Laboratory Sumitomo Chemical Co. Ltd.
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Nakamura Yosuke
Sumitomo Chemical Co. Ltd.environmental Health Science Laboratory
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Okamoto Masahiko
Environmental Health Science Laboratory, Sumitomo Chemical Co. Ltd.
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Fukumori Yoshihiro
Department Of Biology Faculty Of Science Osaka University
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Yamashita K
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
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KATO Hiroshi
Environmental Health Scince Laboratory, Sumitomo Chemical Co., Ltd.,
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YAMASHITA Kazuo
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.,
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NAKAI Kiyoshi
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.,
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Nakai K
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Nakai Kiyoshi
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Kaneko H
Department Of Pediatrics Graduate School Of Medicine Gifu University
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Kawabe H
Department Of Physiology Yamagata University School Of Medicine
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Nakamura Yosuke
Department Of Geophysics Graduate School Of Science Kyoto University
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Okamoto Masahiko
Environmental Health Science Laboratory
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Okamoto Masahiko
Environmental Health Scince Laboratory Sumitomo Chemical Co. Ltd.
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Yamashita Kazuko
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Fukumori Yoshihiro
Department Of Biology Faculty Of Science Kanazawa University
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Nakamura Yosuke
Environ. Health Sci. Lab. Sumitomo Chemical Co. Ltd.
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Kato Hiroshi
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
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