＜Poster＞Modulation of neuronal activities by interactions between neurons and glial cells

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Action potentials are the fundamental signals for relaying information from one region to another inthe nervous system. Action potentials are propagated along axons without decrease of their amplitudes and areconducted with constant velocity depending on axonal diameter and myelin. It is considered that the modulationof fi ring patterns of action potentials in the neural circuit infl uences the information processing in the brain. Weinvestigated the modulatory eff ects of glial cells on the fi ring pattern and the axonal conduction of action potentialsusing rat hippocampal slice preparation. In our previous study, we focused on interneuron / perineuronal glial cellpairs in CA1 region and reported that perineuronal glial cells could be classifi ed into two groups, one group belongastrocytes （perineuronal astrocytes） and the other group oligodendrocytes （perineuronal oligodendrocytes）, basedon their membrane properties and immunohistochemical study. Direct depolarization of perineuronal astrocytesmodulated the directly induced fi ring pattern of the interneuron, with initial facilitation and subsequent suppression.We also studied the oligodendrocytes in the alveus and examined their modulatory effects on the conduction ofaction potentials along axons of CA1 pyramidal cells. Direct repetitive depolarization of oligodendrocytes shortenedthe latencies of action potentials evoked by antidromic stimulation. These results indicate that glial cells infl uencethe firing pattern and axonal conduction of action potentials, and that their effects involve both facilitation andsuppression.

＜Poster＞Modulation of neuronal activities by interactions between neurons and glial cells

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