Proteolytic Release of Latent Transforming Growth Factor-β (TGF-β) Binding Protein-1 (LTBP-1) Fragment in Wound Healing
スポンサーリンク
概要
- 論文の詳細を見る
Transforming growth factor-β (TGF-β) is a potent growth factor that contributes to wound healing. TGF-β is usually secreted in a latent form complexed with its propeptide, latency-associated peptide (LAP), and LAP covalently binds to a molecule of latent TGF-β binding protein (LTBP). Fibrillin-1 sequesters TGF-β within connective tissue microfibrils through interaction with LTBP-1. However, it is not clear whether TGF-β bound to LTBP-1 is available during wound healing. Therefore, we further characterized LTBP-1, the extracellular regulator of TGF-β in wound healing. LTBP-1 fragments were released from skin by plasmin treatment. The LTBP-1 fragment that is similar to plasmin treatment was also detected in a wound surface. The enzymatic activity of plasmin was also detected in wound surfaces. Immunoblotting analyses showed that the LTBP-1 fragment was preferentially detected in a wound surface with proliferating granulation tissues. These results suggest that proteolytic release of LTBP-1 from a wound surface is physiological and important in regulating wound healing.
- 社団法人 日本薬学会の論文
著者
-
Watanabe Ken
Department of Pediatrics, National Cardiovascular Center
-
FUJII Satoshi
Department of Neurosurgery, Yokohama City University School of Medicine
-
Wachi Hiroshi
Faculty Of Technokogy Tokyo University Of Agriculture And Technology
-
Wachi Hiroshi
Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
-
Wachi Hiroshi
Department Of Clinical Chemistry Hoshi College Of Pharmacy
-
ISOGAI Zenzo
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Med
-
Yoneda Masahiko
Aichi Prefectural Collage of Nursing and Health
-
Wachi Hiroshi
星薬科大学 臨床化学教室
-
SEYAMA Yoshiyuki
Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
-
Mizuno Koji
Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences
-
Fujii Satoshi
Department Of Applied Chemistry Faculty Of Engineering Himeji Institute Of Technology
-
Isogai Zenzo
Department Of Dermatology Nagoya City University Medical School
-
Seyama Yoshiyuki
Department Of Clinical Chemistry Hoshi College Of Pharmacy
-
Watanabe Ken
Department Of Civil Engineering Faculty Of Engineering Tokyo Institute Of Technology
-
Watanabe Ken
Department Of Bone And Joint Disease Research Institute National Center For Geriatrics And Gerontology (ncgg)
-
Isogai Zenzo
Department Of Advanced Medicine National Center For Geriatrics And Gerontology
-
SEYAMA YOSHIYUKI
Department of Biochemistry, Tokyo College of Pharmacy
関連論文
- ＜Poster＞Modulation of neuronal activities by interactions between neurons and glial cells
- Doppler Echocardiographic Differentiation of Functional From Anatomical Pulmonary Atresia : Analysis Using Quantitative Parameters
- Molecular Genetic Diagnosis of von Hippel-Lindau Disease: Analysis of Five Japanese Families
- Lower High-Density Lipoprotein Cholesterol is a Significant and Independent Risk for Coronary Artery Disease in Japanese Men
- PJ-195 Decreased Glomerular Filtration Rate is a Significant and Independent Risk for In-Hospital Mortality in Japanese Patients with Acute Myocardial Infarction(PJ033,Preventive Medicine/Epidemiology/Education 1 (H),Poster Session (Japanese),The 73rd Ann
- OJ-223 Risk Factors and the Incidence of Coronary Artery Disease in Japanese Men Aged Less than 50 years(Preventive medicine/Epidemiology/Education-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- A case of aorto-right atrial tunnel associated with aortic and tricuspid atresia
- Intravenous Indomethacin Therapy in Infants With a Patent Ductus Arteriosus Complicating Other Congenital Heart Defects
- Stent Implantation and Subsequent Dilatation for Pulmonary Vein Stenosis in Pediatric Patients
- Plasma Interleukin-6 and Tumor Necrosis Factor-α Can Predict Coronary Endothelial Dysfunction in Hypertensive Patients
- FRS-098 Relationship between Plasma Interleukin-6, Tumor Necrosis Factor-α, and Coronary Endothelial Dysfunction Assessed by , ^O-water PET in Hypertensive(Pathogenesis, Diagnosis and Complication of Hypertension, The 71st Annual Scientific Meeting of
- 3 Quantitative Assessment of Coronary Endothelial Function Using PET and Effects of Angiotensin Receptor Blockade Therapy in Patients with Hypertension(Advances in Cardiovascular Imaging,Symposium 7 (SY7) (I),The 70th Anniversary Annual Scientific Meeting
- Oxygen Permeation of a Dense/Porous Asymmetric Membrane Using La_Ca_CoO_-BaFe_Zr_O_ System
- Inhibition of the Protease Activity of Influenza Virus RNA Polymerase PA Subunit by viral Matrix Protein
- Attenuation of Angiotensin II Mediated JNK Signaling Ameliorates Coronary Perivascular Fibrosis Associated with Insulin Resistance and Obesity(Diabetes/Obesity 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-315 Salutary Effects of Attenuation of Angiotensin II Mediated JNK Signaling on Coronary Perivascular Fibrosis Associated With Insulin Resistance and Obesity(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
- Natural Killer T Cells Accelerate Atherogenesis in Mice
- Up-Regulation of Plasminogen Activator Inhibitor-1 in HepG2 Cells by Interleukin (IL)-1 β and IL-6 and Its Attenuation by HMGCoA Reductase Inhibitor
- Up-Regulation of Plasminogen Activator Ihibitor-1 Production by Hepatocyte Growth Factar in Liver Cells and Its Potential Clinical Implications for Atherothrombosis
- Angiotensin Converting Enzyme (ACE) Inhibition Attenuates Hypofibrinolysis and Reduces Cardiac Perivascular Fibrosis during Development of Diabetic Cardiomyopathy in Obese Mice
- Induction of Plasminogen Activator Inhibitor-1 in Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fibric Acid
- Hypofibrinolysis Downregulates Coronary Capillary Network Remodeling in Aged Obese Diabetic Rats : Implications for Increased Myocardial Vulnerability to Ischemia in Diabetes
- Proinflammatory Cytokines, lnterleukin-1 and -6, and HMGCoA Reductase Inhibitor Up-regulate Plasminogen Activator Inhibitor-1 Production in a Human Liver Cell Line
- Induction of Tissue Factor in Human Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fibric Acid
- Novel Polyethylene Glycol Conjugated S-Nitrosylated Hemoglobin Potently Inhibits Platelet Activation and Adhesion to Artificial Surfaces : Therapeutic Implications for Platelet-Rich Thrombus
- Critical Role of Rho-Associated Protein Kinase and Genistein Sensitive Pathways for Plasminogen Activator Inhibitor-1 Expression in Adipocytes
- Reduced scavenger receptor activity in macrophages from atherosclerosis-resistant strain of mice
- Diminished Left Ventricular Function and Coronary Perivascular Fibrosis Associated with Insulin Resistance do not Require Insulin Receptor Substarte-1 Mediated Signaling
- Augmented phagocytosis and morphological changes by allograft inflammatory factor-1 in activated macrophages : Implications for transplant vasculopathy and atherosclerosis
- Coronary Capillary Remodeling in Non-Insulin-Dependent Diabetic Rats: Amelioration by Inhibition of Angiotensin Converting Enzyme and Its Potential Clinical Implications
- IS064 Angiotensin Converting Enzyme (ACE) Inhibitor Attenuates Microvascular Remodeling During the Development of Diabetic Cardiomyopathy in Genetically Obese Mice
- PJ-440 Sudden Death in Patients with Left Ventricular Dysfunction after Kawasaki Disease(Congenital Heart Disease/Kawasaki's Disease 2 (M) : PJ73)(Poster Session (Japanese))
- Brainstem Congestion Caused by Direct Carotid-Cavernous Fistula : Case Report
- PE-584 Plasma NT-proBNP Concentration is a Sensitive Marker of Diastolic Dysfunction and Arterial Remodeling in Hypertension(Hypertension, clinical-7 (H) PE102,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circula
- PJ-283 Early Detection of High Risk Patients for Atherosclerosis in Untreated Hypertensive Patients(Atherosclerosis, Clinical 3 (IHD) : PJ48)(Poster Session (Japanese))
- Measuring Medium-Sized Muscular Arteries Using a Novel Broadband 15-MHz Linear Array Probe
- Myocardial Blood Volume Assessed by Contrast Echocardiography is Associated with Contractile Reserve in Patients with Idiopathic Dilated Cardiomyopathy(Echo/Doppler 7 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- CCAAT/enhancer Binding Protein δ is Critical for Induction of Plasminogen Activator Inhibitor-1 by Interleukin (IL)-1β and IL-6 in Hepatocytes(Infection/Inflammation/Immunity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Pt/SrRuO_3 Top Electrodes on Ferroelectric Properties of Epitaxial(Pb, La)(Zr, Ti)O_3 Thin Films
- Microsurgical Thromboendarterectomy of the Cavernous Carotid Artery : Case Report and Surgical Technique
- PE-215 Dysregulated Inflammation by NKT Cell-Mediated Pathway of Accelerated Atherogenesis in Unstable Angina may be Amenable to Statin Therapy(Infection/Inflammation/Immunity(02)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japane
- PJ-774 Natural-Killer T Cells are Involved in the Development of Glucose Intolerance and Microalbuminuria in Diet-Induced Obese Mice(Diabetes/Obesity/Metabolic syndrome-12, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-132 Arid5b, Encoding a DNA-Binding Protein, is Upregulated in White Adipose Tissue in Mice Fed an Western Diet(Atherosclerosis, basic-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Platelet Aggregability in Patients with Hypertension Treated with Angiotensin II Type 1 Receptor Blockers
- OJ-115 Hepatocyte Growth Factor and Its Signaling Pathways : Potential Mediators of Increased Plasminogen Activator Inhibitor Type-1 Expression Associated with Insulin Resistance(Thromboembolism/Antithrombotic therapy/Thrombolysis-2 (H) OJ20,Oral Presenta
- OE-220 Induction of Adipose PAI-1 Independent of Insulin Receptor Substrate-1 is the Major Determinant of Hypofibrinolysis in Insulin Resistance(Thromboembolism/Antithrombotic therapy/Thrombolysis-1 (H) OE37,Oral Presentation (English),The 70th Anniversar
- OE-119 Identification of Insulin Receptor Substrate Family Proteins Mediating PAI-1 Production in Cardiac and Adipose Tissues From IRS-1 Null Mice(Diabetes/Obesity/Metabolic syndrome-1 (H) OE20,Oral Presentation (English),The 70th Anniversary Annual Scien
- Daidzein Soy Phytoestrogen, Selectively Ameliorates Obesity-Related Hypertension in Mice without Affecting Other Metabolic Derangements (Diabetes/Obesity 7 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Macrophage Specific Overexpression of Allograft Inflammatory Factor-1 Reduces Atherosclerosis in Vivo (Atherosclerosis, Basic 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Induction of Plasminogen Activator Inhibitor-1 Production by Hepatocyte Growth Factor in Liver and Its Potential Clinical Implications for Angiogenesis (Thrombosis/Thrombolysis 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Induction of Adipose PAI-1 by Hyperinsulinemia in Vivo is the Major Determinant of Hypofibrinolysis in Obesity and Doesn't Require IRS-1(Thrombosis/Thrombolysis 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-173 Natural Killer T Cells and Perforin-Producing CD4T Cells are Diversely Activated in Stable Angina Versus Unstable Angina(Infection/Inflammation/Immunity 1 (H) : OJ20)(Oral Presentation (Japanese))
- OE-065 Regulatory Functions of CD4^+CD28^-T Cells in Stable and Unstable Angina : Implications for Plaque Destabilization(Acute Coronary Syndrome, Basic/Clinical 3 (IHD) : OE9)(Oral Presentation (English))
- Prevalence and Predictors of Renal Artery Stenosis in Patients Undergoing Cardiac Catheterization
- PE-025 Daidzein, Soy Phytoestrogen, Selectively Ameliorates Obesity-Related Hypertension in Mice and Humans(PE005,Metabolic Syndrome 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-330 Daidzein, Soy Phytoestrogen, Selectively Ameliorates Obesity-Related Hypertension in Mice and Humans Without Affecting Other Metabolic Derangements(Hypertension, clinical(08)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Jap
- Alopecia Universalis in a Patient with Psoriasis Vulgaris
- Multiple Benign Keratoses during Cyclosporin Therapy for Psoriasis
- PE-181 CCAAT-Enhancer Binding Protein Delta Mediates the Up-regulation of Plasminogen Activator Inhibitor-1 Induced by lnterleukin-6 and its Attenuation by Mevastatin(Infection/Inflammation/Immunity 2 (H) : PE31)(Poster Session (English))
- Long-Term Outcome of Isolated Congenital Complete Atrioventricular Block Pacing Since Neonatal Period : Experience at a Single Japanese Institution
- Proteolytic Release of Latent Transforming Growth Factor-β (TGF-β) Binding Protein-1 (LTBP-1) Fragment in Wound Healing
- PE-214 Pravastatin and Atorvastatin Were Equivalent in Reducing Inflammatory Markers in Acute Coronary Syndrome Despite Differences in Lowering LDL : PROVE-J Study(Infection/Inflammation/Immunity(02)(H),Poster Session(English),The 72nd Annual Scientific M
- OE-095 Natural Killer T Cells are Involved in Macrophage Infiltration in Visceral Adipose Tissue and Glucose Intolerance in Diet-Induced Obese Mice(Diabetes/Obesity/Metabolic syndrome(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of
- OE-119 Natural killer T cells accelerate atherogenesis in mice by alterating cytokine production profile(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
- In Vivo Echocardiographic Detection of Cardiovascular Lesions in Apolipoprotein E-Knockout Mice Using a Novel High-Frequency High-Speed Echocardiography Technique
- OJ-214 Differences in Cardiovascular Risk Factors of Coronary Artery Disease : A Study on Ethnic Differences in Subclinical Hypofibrinolysis and Inflammation(Blood Coagulation/Fibrinolysis (IHD) : OJ24)(Oral Presentation (Japanese))
- OJ-209 Hepatocyte Growth Factor Activates PAI-1 Production in Human Liver Cells Through the MEK and Tyrosine Kinase-dependent Signaling Pathways(Blood Coagulation/Fibrinolysis (IHD) : OJ24)(Oral Presentation (Japanese))
- OE-318 Maintenance of Cardiac and Adipose PAI-1 Expression Despite the Lack of IRS-1 : a Knockout Mouse Study(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
- Increased Expression of Plasminogen Activator Inhibitor-1 by Mediators of the Acute Phase Response: a Potential Progenitor of Vasculopathy in Hypertensives
- Selective Ablation of IRS-1 Decreases Cardiac Contractility without Attenuating PAI-1 Expression or Perivascular Fibrosis
- Diminished Fibrinolysis and Thrombosis : Clinical Implications for Accelerated Atherosclerosis
- -278-THE ROLE OF FATTY ACID BINDING PROTEIN IN HYPOXIC RAT MYOCYTE INJURY : Ischemic Heart Disease II : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -P160- ANALYSIS OF A MEMBRANE RECEPTOR RESPONSIBLE FOR FATTY ACID BINDING IN RAT MYOCARDIUM
- -346- SHR KIDNEY FATTY ACID BINDING PTOTEIN EXHIBITS DIFFERENCES IN LIGAND AFFINITY AND ENDOGENEOUS FATTY ACID COMPOSITIONS
- OJ-190 Macrophage Specific Overexpression of Allograft Inflammatory Factor-1 in Transgenic Mice Promotes Phagocytotic Activity Following Thioglycollate Stimulation and Regulate Atherosclerotic Progression(Atherosclerosis, Basic 2 (IHD) : OJ22)(Oral Presen
- Preparation and Pyroelectric Properties of Mn-Modified (Pb, La)(Zr, Ti)O_3 (PLZT) Ceramics
- PREPARATION AND PYROELECTRIC PROPERTIES OF ZIRCONIUM-MODIFIED LEAD LANTHANUM TITANATE CERAMICS AND THIN FILMS
- La1-xSrxCo0.2Fe0.8O3-δの電気特性、結晶構造と酸素不定比性
- 4 PAI-1 is the Principal Adipocytokine and New Therapeutic Target in Mets : Novel Marker of Abdominal Fat and Initiator of Atherosclerosis(Symposium 3 (SY-03) (IHD) Metabolic Syndrome and Atherosclerosis,Special Program,The 72nd Annual Scientific Meeting
- PJ-399 Plasma NT-proBNP Concentration is a Sensitive Marker of Diastolic Dysfunctio n and Arterial Remodeling in Hypertension(Neurohumoral factors-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-413 Identification of Insulin Receptor Substrate Family Proteins Mediating PAI-1 Production in Cardiac and Adipose Tissues From IRS-1 Null Mice(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
- PE-180 Induction of Adipose PAI-1 Independent of Insulin Receptor Substrate-1 is the Major Determinant of Hypofibrinolysis in Insulin Resistance(Thromboembolism/Antithrombotic therapy/Thrombolysis-3, The 71st Annual Scientific Meeting of the Japanese Circ
- Colestimide, an anion exchange resin agent, can decrease the number of LDL particles without affecting their size in patients with hyperlipidemia
- Detection of AML1/MTG8 fusion gene of spinal granulocytic sarcoma in a nonleukemic patient using the real-time polymerase chain reaction
- Presence of Endothelial Dysfunction Is the Major Determinant of Maladaptive Vascular Remodeling in Brachial Arteries of Untreated Hypertensive Patients
- Vascular Remodeling of the Brachial Artery and its Relation to Endothelial Function in Untreated Hypertensive Patients
- Brachial Artery Intima-Medial Thickening and Preserved Fibrinolysis Indicate Adaptive Vascular Remodeling in Japanese Uncomplicated Hypertensives
- 2P-114 分子動力学シミュレーションによるDNAの柔らかさの塩基配列依存性と水和パターンの関係解析(核酸・構造物性,第46回日本生物物理学会年会)
- Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
- The Temperature-Dependent Modulation of an Inhibitory Circuit in Hippocampal Slices as Revealed by a Population Spike Recording Is Mediated by Extracellular Adenosine
- -92-RAT KIDNEY FATTY ACID BINDING PROTEIN : INCREASED BINDING ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS
- EFFECTS OF YTTRIUM AND SODIUM ADDITION ON PREPARATION AND HUMIDITY SENSITIVITY OF POROUS APATITE CERAMICS
- Relationship between Pyroelectric Properties and Electrode Sizes in (Pb,La)(Zr,Ti)O_3 (PLZT) Thin Films
- Preparation and Pyroelectric Properties of (Pb, La)(Zr, Ti)O_3 (PL, ZT) Thin Films
- PREPARATION OF LANTHANUM-AND MAGNESIUM-MODIFIED LEAD TITANATE CERAMICS AND THIN FILMS, AND THEIR PYROELECTRIC PROPERTIES
- OE-221 Statins Reduce Interleukin (IL)-1 β and IL-6-Induced Plasminogen Activator Inhibitor-1 in Hepatocytes Through C/EBPδ(Thromboembolism/Antithrombotic therapy/Thrombolysis-1 (H) OE37,Oral Presentation (English),The 70th Anniversary Annual Scientific M
- Cooperativity between activation of metabotropic glutamate receptors and NMDA receptors in the induction of LTP in hippocampal CA1 neurons
- Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro
- Binding of sulphatide to recombinant haemagglutinin of influenza A virus produced by a baculovirus protein expression system
- Association of Cardiovascular Risk Factors and Endothelial Dysfunction in Japanese Hypertensive Patients: Implications for Early Atherosclerosis