Direct Enantiomeric Separation of Platelet-activating Factor Receptor Antagonist SM-10661 by Ligand-exchange High-performance Liquid Chromatography with a Copper(II) N,S-Dioctyl-D-penicillamine Complex
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概要
- 論文の詳細を見る
The enantiomeric separation of SM-10661, a platelet activating factor receptor antagonist, was investigated by HPLC using ligand-exchange chiral stationary phases. The stereoisomers of SM-10661could all be separated by ligand-exchange HPLC with a Cu(II)N, S-dioctyl-D-penicillamine complex (Sumichiral OA-5000). The mechanism for the resolution includes the involvement of hydrophobic interactions between SM-10661 and Cu(II) D-penicillamine.
- 社団法人日本農芸化学会の論文
- 1995-09-23
著者
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Doi T
Otsuka Pharmaceutical Co. Saga Jpn
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Okamoto Masahiko
Environmental Health Science Laboratory, Sumitomo Chemical Co. Ltd.
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Ueda Youichi
Environmental Health Science Laboratory
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Takahashi Ken-Ichi
Environmental Health Science Laboratory
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Nakazawa Hiroshi
Environmental Health Science Laboratory
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Doi Tadashi
Environmental Health Science Laboratory
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Okamoto Masahiko
Environmental Health Science Laboratory
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