A QUANTITATIVE COMPARISON OF INDUCTION AND CHALLENGE CONCENTRATIONS INDUCING A 50% POSITIVE RESPONSE IN THREE SKIN SENSITIZATION TESTS; THE GUINEA PIG MAXIMIZATION TEST, ADJUVANT AND PATCH TEST AND BUEHLER TEST
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概要
- 論文の詳細を見る
The sensitivities of three skin sensitization tests such as the Guinea pig maximization test (GPMT), Adjuvant and patch test (APT) and Buehler test (BT), were quantitatively compared with reference to induction and challenge concentrations. Four chemicals which had different physico-chemical properties (octanol-water partition coefficient (logP) and reactivity with NH_2-group) were used in order to clarify the effect of the physico-chemical properties of chemicals on the sensitivity of the different methods. The induction concentrations inducing a 50% positive response (IC_<50>) demonstrated extreme variation with the three methods. For example, the BT/GPMT ratio of IC_<50> values for 2,4-dinitrochlorobenzene was 33, whereas that for maleic anhydride was 300,000. The results were thought to be caused by difference properties such as the logP and reactivity of chemicals. This correlation was confirmed by using 2-dodecen-1-yl succinic anhydride, which had the same reactivity but higher logP than that of maleic anhydride. On the other hand, the challenge concentrations inducing 50% positive responses (CC_<50>) were less affected by the methods and the BT/GPMT ratios for CC_<50> values were all within a 10-fold range. These results suggest that the sensitivity might be strongly different with reference to induction concentration, but not challenge concentration among the three methods.
- 日本トキシコロジー学会の論文
- 1999-05-10
著者
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Kaneko Hideo
Department Of Pediatrics Graduate School Of Medicine Gifu University
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Kaneko H
The Society Of Non-traditional Technology
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Kaneko Hideo
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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Kaneko H
Environmental Health Science Laboratory Sumitomo Chemical Co. Ltd.
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KANEKO Hideo
Sumitomo Chemical Co.,Ltd.
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Nakamura Yosuke
Environmental Health Scince Laboratory Sumitomo Chemical Co. Ltd.
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Nakamura Yosuke
Sumitomo Chemical Co. Ltd.environmental Health Science Laboratory
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Isobe Naohiko
Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory
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Kaneko H
Department Of Pediatrics Graduate School Of Medicine Gifu University
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HIGAKI Tamaki
Sumitomo Chemical Co., Ltd. Environmental Health Science Laboratory
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KATO Hiroshi
Sumitomo Chemical Co., Ltd. Environmental Health Science Laboratory
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KISHIDA Fumio
Sumitomo Chemical Co., Ltd. Environmental Health Science Laboratory
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KOGISO Sigefumi
Sumitomo Chemical Co., Ltd. Environmental Health Science Laboratory
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Kishida Fumio
Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory
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Higaki Tamaki
Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory
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Higaki Tamaki
Sumitomo Chemical Co. Ltd.
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Kogiso Sigefumi
Sumitomo Chemical Co. Ltd. Environmental Health Science Laboratory
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Nakamura Yosuke
Department Of Geophysics Graduate School Of Science Kyoto University
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Kaneko Hideo
Sumitomo Chemical Co. Ltd.
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Nakamura Yosuke
Sumitomo Chemical Co. Ltd.
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