SPECIES DIFFERENCE IN SUSCEPTIBILITY TO PHORBOL MYRISTATE ACETATE-INDUCED LEUKOPENIA AND LUNG INJURY : RAT VS. DOG
スポンサーリンク
概要
- 論文の詳細を見る
Phorbol myristate acetate (PMA) was administered intravenously in a single dose to rats (400μg/kg) and in a single and repeated doses to dogs (40μg/kg). Severe leukopenia was observed in both species. The leukopenia in rats was due to a decreased number of both lymphocytes and neutrophils while the leukopenia in dogs was mainly due to a decreased number of neutrophils. The rats recovered from leukopenia much faster than the dogs. The dog which received a single injection developed focal fibrosis in the lungs, Rats showed only slight localized hemorrhage in the lungs, although the rats received a ten-fold larger dose of PMA than the dogs. Lungs of dogs which received multiple injections revealed severe hemorrhage lesions in most alveoli. Lung lesions induced by PMA are thought to be mediated by activated leukocytes. This suggests that the severity of lung lesion correlates with the degree and duration of neutropenia. In conclusion, intravenous administration of PMA caused lung damage in rats and dogs. However, rats show much less sensitivity to PMA than dogs, resulting from the different response of leukocytes to PMA.
- 日本トキシコロジー学会の論文
- 1992-11-25
著者
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矢本 敬
Medicinal Safety Research Laboratories Daiichi Sankyo Co. Ltd.
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TAKAOKA Masaya
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
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MANABE Sunao
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
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YAMOTO Takashi
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
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Yamashita Kazuo
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd.
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山下 和男
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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YANAI Tokuma
Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University
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Yanai T
Department Of Veterinary Pathology Gifu University
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Totsuka Y
Cancer Prevention Basic Research Project
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TARUMI Chitoshi
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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MASUDA Hiroshi
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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Masuda Hiroshi
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
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Yamachika Takasuke
Division Of Oncological Pathology Aichi Cancer Center Research Institute
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高岡 雅哉
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Takaoka Masaya
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
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Masuda H
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Yamoto Takashi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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LIN Young
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, The Ohio State
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MATSUNUMA Naochika
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
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Yamashita Kazuo
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
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Matsunuma Naochika
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
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Matsunuma Naochica
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Matsunuma Naochika
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Lin Young
Department Of Veterinary Physiology And Pharmacology College Of Veterinary Medicine The Ohio State U
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Yamashita K
Taiho Pharmaceutical Co. Ltd. Tokushima Jpn
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Matsunuma Naochika
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co Ltd.
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Tarumi Chitoshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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Tarumi Chitoshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd
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Masuda H
Department Of Biosciences And Technology Faculty Of Agriculture Iwate University
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Totsuka Yukari
国立がん研究センター研究所 発がんシステム研究分野
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Matsunuma Naochika
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
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Masuda Hiroshi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
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YANAI Tokuma
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
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