EFFECTS OF ACETONE(AT) ON HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES IN BEAGLE DOGS
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1993-11-25
著者
-
矢本 敬
Medicinal Safety Research Laboratories Daiichi Sankyo Co. Ltd.
-
TAKAOKA Masaya
Lab.Anim.Sci. & Toxicol.Labs.Sankyo Co., Ltd.
-
YAMOTO Takashi
Lab.Anim.Sci. & Toxicol.Labs.Sankyo Co., Ltd.
-
OHASHI Yoshihiko
Lab.Anim.Sci. & Toxicol.Labs.Sankyo Co., Ltd.
-
MANABE Sunao
Lab.Anim.Sci. & Toxicol.Labs.Sankyo Co., Ltd.
-
真鍋 淳
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
-
大橋 芳彦
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
真鍋 淳
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
SUGANO Akinaga
Lab.Anim.Sci.& Toxicol.Labs.Sankyo Co., Ltd.
-
YASUDA Mitsuya
Lab.Anim.Sci.& Toxicol.Labs.Sankyo Co., Ltd.
-
Tatematsu M
愛知県がんセンター研究所 腫瘍病理学部
-
Sugano Akinaga
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
-
Tatematsu Masae
愛知県がんセンター研究所 腫瘍病理学部
-
Yasuda Mitsuya
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
高岡 雅哉
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Takaoka Masaya
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
-
Yamoto Takashi
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Ohashi Yoshihiko
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
-
Oohashi Yoshihiko
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
-
Makita Takashi
Dept. Vet. Anat. Yamaguchi Univ.
関連論文
- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- Toxicokintic and toxicodynamic analysis of clofibrate based on free drug concentrations in nagase analbuminemia rats (NAR)
- An Attempt to Predict the Response of Human Glutathione S-Transferase (GST) to Chemical Inducers Using Transgenic Rats Harboring Human GST Gene
- Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
- Lack of association between CpG island methylator phenotype in human gastric cancers and methylation in their background non-cancerous gastric mucosae
- Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils
- Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
- Gastric adenocarcinoma with chief cell differentiation
- Effects of eradication of Helicobacter pylori on gastric carcinogenesis in experimental models
- Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils
- Significant Factors on Gastric Carcinogenesis Revealed by Experimental Animal Models
- Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils
- Colonic and small-intestinal phenotypes in gastric cancers : Relationships with clinicopathological findings
- Susceptibility of Heterozygous and Nullizygous p53 Knockout Mice to Chemical Carcinogens : Tissue Dependence and Role of p53 Gene Mutations
- Coexistence of gastric-and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach
- Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils
- P6-38 Relationship between hepatic enzyme induction and carcinogenicity in the p53 deficient mice treated with aminophenylnorharman(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- β-Catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils
- Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa
- Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
- β-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas
- Tissue-dependent susceptibility of p53 knockout mice to chemical-induced carcinogenesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effect of early eradication on Helicobacter pyloirirelated gastric carcinogenesis in Mongolian gerbils
- Gastric Carcinogenesis and Intestinalization Induced by N-methyl-N-nitrosourea in the Senescence-Accelerated Mouse (SAMP3)
- Earlier Helicobacter pylori Infection Increases the Risk for the N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in Mongolian Gerbils
- Tongue Carcinogenic Susceptibility of p53 Deficient Mice to Methyl-n-amylnitrosamine
- Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenesis in Mongolian Gerbils
- Appearance of Osteonectin-expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N-Methyl-N'-nitro-N-nitrosoguanidine
- The Effects of Allyl Alcohol-induced Cell Proliferation for Detection of Initiation Activities of Chemicals in Rat Liver
- CHARACTERIZATION OF RESISTANCE TO BROMOBENZENE-INDUCED HEPATOTOXICITY BY MICROARRAY
- RESISTANCE TO THE SKELETAL MUSCLE INJURY EXPRESSED BY REPEATED TREATMENT WITH COMPOUND A THAT HAS HMG-CoA REDUCTASE INHIBITORY ACTIVITY
- P7-41 Skeletal muscle injury caused by compound A completely recovers in spite of further treatment?(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE (S,R)-SULFOXIMINE
- Involvement of Drug Transporters in the Acquired Resistance to Bromobenzene-induced Hepatotoxicity (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 21C-04-2 Correlation between Localization of CYP1A1/2 and Aryl Hydrocarbon Receptor in the Liver Lobule of Rats Treated with 3-methylcholantherene(3MC) or β-Naphthoflavone (BNF).
- Effects of Growth Hormone on Bone in Mini Rats
- Comparison of Bone Changes between Neonatally Monosodium Glutamate-Treated Rats and Mini Rats
- Effects of phenobarbital, a drug-metabolizing enzymes inducer, on hepatic DNA ploidy in hepatectomized rats
- Effect of Glucose Feeding on Regenerating Rat Liver Following Partial Hepatectomy
- "P-36 Hepatic response to continuous cytochrome P450 inhibition in rats sequentially treated with α-hederin.
- Relationship of induction of phase II enzymes to decrease in gap-junctional intercellular communication in rat liver treated with a disinfectant, Etridiazole.
- Correlation between decrease in intercellular communication and phase I enzyme induction in rat liver treated with phenobarbital : an examination of the reversibility during PB-withdrawal.
- DOES GLUCOSE FEEDING POTENTIATE THE TOXICITY OF HEPATOTOXICANTS?
- Induction of Glutathione S-Transferases and Hepatocellular Proliferating Activities in the Rat Liver Treated with tert-Butylated Hydroxyanisole, 1, 2-Bis(2-Pyridyl)Ethylene, and Phenobarbital
- Gene Expression Profiles in the Liver, Placenta and Fetal Liver in Pregnant Rats Treated with T-2 Toxin (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone
- トログリタゾンによる肝障害の機序解明への薬物動態学的アプローチ - UGTの多型は肝障害の要因となり得るか? -
- Acquired Resistance to Bromobenzene Hepatotoxicity by Repeated Treatment of Rats with Bromobenzene
- EFFECT OF TROGLITAZONE ON THE LIVER OF A GUNN RAT MODEL OF GENETIC ENZYME POLYMORPHISM
- Sex difference and effect of growth hormone on daily fluctuation of hepatic P450 monooxygenase activities in rats.
- Comparison of the Induction Profile of Hepatic Drug-metabolizing Enzymes Between Piperonyl Butoxide and Phenobarbital in Rats
- 3A-03 Effect of Adrenalectomy on Daily Fluctuation of Liver Metabolic Enzyme Activities in F344 Rats
- "B-7 Daily fluctuation of liver metabolic enzymes in F344 rats.
- "A-9 Changes of the liver and kidney in rats treated with tert-butylated hydroxyanisole (BHA).
- INVESTIGATION ON RENAL GLUTATHIONE S-TRANSFERASE ACTIVITY OF DOGS : RELATIONSHIP WITH ITS HEPATIC ACTIVITY
- LOW GLUTATHIONE S-TRANSFERASE ACTIVITY IN DOG LIVER AND THE MONITORING METHOD
- SEX DIFFERENCE IN INDUCIBILITY OF LIVER DRUG METABOLIZING ENZYMES IN RATS : In particular emphasis on Phase II enzymes
- NECESSARY PERIOD FOR RE-ENTRAINMENT IN RATS AFTER THE REVERSE OF LIGHT-DARK CYCLE : A METHOD TO DETERMINE CONCENTRATIONS OF A TEST SUBSTANCE IN THE BLOOD
- EFFECTS OF ACETONE(AT) ON HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES IN BEAGLE DOGS
- Collaborative work on evaluation of ovarian toxicity : 8) Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats
- EFFECT OF DIFFERENT DOSES OF β-NAPHTHOFLAVONE(BNF) ON THE LOCALIZATION OF CYTOCHROME P-450 ISOZYMES IN THE LIVER LOBULE OF RATS
- 323 AN IMMUNOHISTOCHENICAL STUDY ON THE LOCALIZATIONS OF CHEMICAL-INDUCIBLE CYTOCHRONE P-450 WITHIN THE RAT LIVER
- 102 AGE-RELATED CHANGES IN THE SUSCEPTIBILITY OF MALE F344 RAT LIVER TO PEROXISOME PROLIFERATOR, CLOFIBRIC ACID
- 老齢B6C3F1マウスの脳小血管における自然発生鉱物質沈着症
- 肝毒性
- 医薬品開発における毒性評価のバイオマーカー
- Effects of Neonatal Administration of Monosodium Glutamate on Bone in Rats
- ラット甲状腺濾胞上皮細胞に観察された細胞質内水腫の1例(短報)
- 1, 2, 4-Triazoleの3位置換基のラットに対する甲状腺腫誘発作用の比較
- 老齢マウス視床における鉱物質沈着症のX線微小部分析
- Decrease in protein binding and its effect on toxicokinetics (TK)/toxicodynamics (TD) of diclofenac and propranolol in pregnant rats
- Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs
- Toxicogenomic Biomarkers for Liver Toxicity
- Effect of feeding condition on gene expression analysis using DNA chip.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- APPLICATION OF REPEATED BLOOD COLLECTION TECHNIQUE FROM A TAIL VEIN TO TOXICOKINETIC STUDIES IN THE RAT TREATED ORALLY WITH PHENOBARBITAL
- SPECIES DIFFERENCE IN SUSCEPTIBILITY TO PHORBOL MYRISTATE ACETATE-INDUCED LEUKOPENIA AND LUNG INJURY : RAT VS. DOG
- Gene expression analysis on rat livers treated with L-buthionine (S, R)-sulfoximine : investigation of data compatibility between RG U34A and RAE 230A GeneChips(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Gene expression analysis in rat livers and immune organs treated with isoniazid, phenytoin, hydralazine hydrochloride or chlorpromazine(Proceedings of the 32nd Annual Meeting)
- P6-47 Relationship between hepatic glutathione content and gene expression profile in F344 male rats treated with L-Buthionine(S,R)-sulfoximine(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Gene expressions in F344 rat livers treated with acetaminophen or cycloheximide (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effect of aging on gene expression profile in rat livers treated with phenobarbital or clofibrate (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Osteosarcomas in the Lungs of an ICR Mouse
- A11 Hepatic foamy cell in Fischer 344 rats : Its age-related morphological properties.
- Analysis of nephropathy using DNA chip.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Gene Expression Analysis on the Rat Liver Treated with Clofibrate or Phenobarbital.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Immunohistochemical Staining Methods for Connexin32 on Formalin-Fixed Paraffin-Embedded Sections
- Biochemical and immunohistochemical studies on constitutional changes of P450 isozymes during postnatal development in rat liver.
- Pulmonary Histiocytic Sarcoma in Two Aged Dogs of a Beagle Colony
- Relationship between hepatocellular apoptosis and Kupffer cell activation in the livers of rats treated with cycloheximide(Proceedings of the 32nd Annual Meeting)
- Toxicogenoimics, Proteomics and Metabonomics(Toxicity Screening Strategy in Early Stage Drug Development : Current Situation and Perspective, Proceedings of the 32nd Annual Meeting)
- Comparison of Age-Related Bone Changes between Mini Rats and Wistar Rats
- "P-28 Study of reversibility in rat bone changes induced by beta-aminopropionitrile or aminoacetonitrile
- 215 CORRELATION BETWEEN PERIPORTAL NECROSIS AND INDUCTION OF MICROSOMAL ENZYMES AFTER REPEATED ADMINISTRATION OF BUTYLATED HYDROXYTOLUENE(BHT)
- Effects of monosodium glutamate pretreament on the rat liver changes by clofibrate administration.
- 324 EFFECTS OF PHENOBARBITAL(PB) AND PARTIAL HEPATECTOMY(PH) ON HEPATIC MICROSOMAL DRUG METABOLIZING ENZYMES IN BEAGLE DOGS
- Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses
- Bronchioloalveolar Carcinoma in an Aged Beagle Dog
- Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats
- Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys
- Toxicogenomic Biomarkers for Liver Toxicity