医薬品開発における毒性評価のバイオマーカー
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- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- Toxicokintic and toxicodynamic analysis of clofibrate based on free drug concentrations in nagase analbuminemia rats (NAR)
- An Attempt to Predict the Response of Human Glutathione S-Transferase (GST) to Chemical Inducers Using Transgenic Rats Harboring Human GST Gene
- CHARACTERIZATION OF RESISTANCE TO BROMOBENZENE-INDUCED HEPATOTOXICITY BY MICROARRAY
- RESISTANCE TO THE SKELETAL MUSCLE INJURY EXPRESSED BY REPEATED TREATMENT WITH COMPOUND A THAT HAS HMG-CoA REDUCTASE INHIBITORY ACTIVITY
- P7-41 Skeletal muscle injury caused by compound A completely recovers in spite of further treatment?(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE (S,R)-SULFOXIMINE
- 21C-04-2 Correlation between Localization of CYP1A1/2 and Aryl Hydrocarbon Receptor in the Liver Lobule of Rats Treated with 3-methylcholantherene(3MC) or β-Naphthoflavone (BNF).
- Effects of Growth Hormone on Bone in Mini Rats
- Comparison of Bone Changes between Neonatally Monosodium Glutamate-Treated Rats and Mini Rats
- Effects of phenobarbital, a drug-metabolizing enzymes inducer, on hepatic DNA ploidy in hepatectomized rats
- Effect of Glucose Feeding on Regenerating Rat Liver Following Partial Hepatectomy
- "P-36 Hepatic response to continuous cytochrome P450 inhibition in rats sequentially treated with α-hederin.
- Relationship of induction of phase II enzymes to decrease in gap-junctional intercellular communication in rat liver treated with a disinfectant, Etridiazole.
- Correlation between decrease in intercellular communication and phase I enzyme induction in rat liver treated with phenobarbital : an examination of the reversibility during PB-withdrawal.
- DOES GLUCOSE FEEDING POTENTIATE THE TOXICITY OF HEPATOTOXICANTS?
- Induction of Glutathione S-Transferases and Hepatocellular Proliferating Activities in the Rat Liver Treated with tert-Butylated Hydroxyanisole, 1, 2-Bis(2-Pyridyl)Ethylene, and Phenobarbital
- Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone
- トログリタゾンによる肝障害の機序解明への薬物動態学的アプローチ - UGTの多型は肝障害の要因となり得るか? -
- EFFECT OF TROGLITAZONE ON THE LIVER OF A GUNN RAT MODEL OF GENETIC ENZYME POLYMORPHISM
- Sex difference and effect of growth hormone on daily fluctuation of hepatic P450 monooxygenase activities in rats.
- Comparison of the Induction Profile of Hepatic Drug-metabolizing Enzymes Between Piperonyl Butoxide and Phenobarbital in Rats
- "B-7 Daily fluctuation of liver metabolic enzymes in F344 rats.
- "A-9 Changes of the liver and kidney in rats treated with tert-butylated hydroxyanisole (BHA).
- LOW GLUTATHIONE S-TRANSFERASE ACTIVITY IN DOG LIVER AND THE MONITORING METHOD
- SEX DIFFERENCE IN INDUCIBILITY OF LIVER DRUG METABOLIZING ENZYMES IN RATS : In particular emphasis on Phase II enzymes
- EFFECTS OF ACETONE(AT) ON HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES IN BEAGLE DOGS
- Collaborative work on evaluation of ovarian toxicity : 8) Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats
- EFFECT OF DIFFERENT DOSES OF β-NAPHTHOFLAVONE(BNF) ON THE LOCALIZATION OF CYTOCHROME P-450 ISOZYMES IN THE LIVER LOBULE OF RATS
- 323 AN IMMUNOHISTOCHENICAL STUDY ON THE LOCALIZATIONS OF CHEMICAL-INDUCIBLE CYTOCHRONE P-450 WITHIN THE RAT LIVER
- 老齢B6C3F1マウスの脳小血管における自然発生鉱物質沈着症
- 肝毒性
- 医薬品開発における毒性評価のバイオマーカー
- Effects of Neonatal Administration of Monosodium Glutamate on Bone in Rats
- ラット甲状腺濾胞上皮細胞に観察された細胞質内水腫の1例(短報)
- 1, 2, 4-Triazoleの3位置換基のラットに対する甲状腺腫誘発作用の比較
- 老齢マウス視床における鉱物質沈着症のX線微小部分析
- Toxicogenomic Biomarkers for Liver Toxicity
- Gene expression analysis on rat livers treated with L-buthionine (S, R)-sulfoximine : investigation of data compatibility between RG U34A and RAE 230A GeneChips(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Gene expression analysis in rat livers and immune organs treated with isoniazid, phenytoin, hydralazine hydrochloride or chlorpromazine(Proceedings of the 32nd Annual Meeting)
- P6-47 Relationship between hepatic glutathione content and gene expression profile in F344 male rats treated with L-Buthionine(S,R)-sulfoximine(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Gene expressions in F344 rat livers treated with acetaminophen or cycloheximide (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effect of aging on gene expression profile in rat livers treated with phenobarbital or clofibrate (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Osteosarcomas in the Lungs of an ICR Mouse
- Analysis of nephropathy using DNA chip.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Gene Expression Analysis on the Rat Liver Treated with Clofibrate or Phenobarbital.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Immunohistochemical Staining Methods for Connexin32 on Formalin-Fixed Paraffin-Embedded Sections
- Biochemical and immunohistochemical studies on constitutional changes of P450 isozymes during postnatal development in rat liver.
- Pulmonary Histiocytic Sarcoma in Two Aged Dogs of a Beagle Colony
- Relationship between hepatocellular apoptosis and Kupffer cell activation in the livers of rats treated with cycloheximide(Proceedings of the 32nd Annual Meeting)
- Toxicogenoimics, Proteomics and Metabonomics(Toxicity Screening Strategy in Early Stage Drug Development : Current Situation and Perspective, Proceedings of the 32nd Annual Meeting)
- Comparison of Age-Related Bone Changes between Mini Rats and Wistar Rats
- "P-28 Study of reversibility in rat bone changes induced by beta-aminopropionitrile or aminoacetonitrile
- Effects of monosodium glutamate pretreament on the rat liver changes by clofibrate administration.
- 324 EFFECTS OF PHENOBARBITAL(PB) AND PARTIAL HEPATECTOMY(PH) ON HEPATIC MICROSOMAL DRUG METABOLIZING ENZYMES IN BEAGLE DOGS
- Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses
- Bronchioloalveolar Carcinoma in an Aged Beagle Dog
- Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats
- Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys