Correlation between decrease in intercellular communication and phase I enzyme induction in rat liver treated with phenobarbital : an examination of the reversibility during PB-withdrawal.
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1995-09-25
著者
-
Sugiura Tomomi
Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.
-
IGARASHI Isao
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
-
WATANABE Toshiyuki
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
-
TANAKA Kohji
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
-
OHASHI Yoshihiko
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
-
MANABE Sunao
Laboratory Animal Science & Toxicology Laboratories, Sankyo Co., Ltd.
-
Kimura Kunio
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd.
-
Sugiura Tomomi
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
Sato Satoko
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd.
-
真鍋 淳
Medicinal Safety Research Laboratories Daiichi-sankyo Co. Ltd.
-
Kimura Kunio
Lab. Anim. Sci. And Tokicol. Lab. Sankyo Co. Ltd.
-
大橋 芳彦
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
真鍋 淳
Laboratory Animal Science And Toxicology Laboratories Sankyo Co. Ltd.
-
Sharyo Satoru
Medicinal Safety Research Labs. Sankyo Co. Ltd.
-
Sharyo Satoru
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Tanaka K
Institute Of Earth And Space Science Graduate School Of Science Osaka University
-
田中 宏治
Med.safe.res.labs. Sankyo Co. Ltd. Of Shizuoka Pref.
-
五十嵐 功
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Tanaka K
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University:(present Office
-
Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
-
Tanaka Kohji
Med.safe.res.labs. Sankyo Co. Ltd. Of Shizuoka Pref.
-
Sugiura Tomomi
Lab. Anim. Sci. And Tokicol. Lab. Sankyo Co. Ltd.
-
Kimura Kunio
Lab.anim.sci.& Toxicol.labs.sankyo Co. Ltd.
-
Tanaka Keiichi
Dep. Toxicol. Grad. School Pharmaceut. Sci. Osaka Univ.
-
渡辺 稔之
Medicinal Safety Research Laboratories Sankyo Co. Ltd.
-
Igarashi Isao
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
-
Ohashi Yoshihiko
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
-
Kojitani Takatoshi
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
-
Kimura Kunio
Laboratory Animal Science And Toxicology Laboratories
-
Sato Satoko
Laboratory Animal Science & Toxiology Laboratories Sankyo Co. Ltd.
-
Oohashi Yoshihiko
Lab. Anim. Sci. & Toxicol. Lab. Sankyo Co. Ltd.
-
Igarashi Isao
三共安全性研究所
関連論文
- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- Toxicokintic and toxicodynamic analysis of clofibrate based on free drug concentrations in nagase analbuminemia rats (NAR)
- An Attempt to Predict the Response of Human Glutathione S-Transferase (GST) to Chemical Inducers Using Transgenic Rats Harboring Human GST Gene
- Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys
- CHARACTERIZATION OF RESISTANCE TO BROMOBENZENE-INDUCED HEPATOTOXICITY BY MICROARRAY
- RESISTANCE TO THE SKELETAL MUSCLE INJURY EXPRESSED BY REPEATED TREATMENT WITH COMPOUND A THAT HAS HMG-CoA REDUCTASE INHIBITORY ACTIVITY
- P7-41 Skeletal muscle injury caused by compound A completely recovers in spite of further treatment?(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE (S,R)-SULFOXIMINE
- Involvement of Drug Transporters in the Acquired Resistance to Bromobenzene-induced Hepatotoxicity (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 21C-04-2 Correlation between Localization of CYP1A1/2 and Aryl Hydrocarbon Receptor in the Liver Lobule of Rats Treated with 3-methylcholantherene(3MC) or β-Naphthoflavone (BNF).
- Effects of Growth Hormone on Bone in Mini Rats
- Comparison of Bone Changes between Neonatally Monosodium Glutamate-Treated Rats and Mini Rats
- Effects of phenobarbital, a drug-metabolizing enzymes inducer, on hepatic DNA ploidy in hepatectomized rats
- Effect of Glucose Feeding on Regenerating Rat Liver Following Partial Hepatectomy
- 2C-19 The increase in unirary oxcretion of 6 β-hydroxycortisol in common marmosets as a marker of hepatic CYP3A induction
- "P-36 Hepatic response to continuous cytochrome P450 inhibition in rats sequentially treated with α-hederin.
- Relationship of induction of phase II enzymes to decrease in gap-junctional intercellular communication in rat liver treated with a disinfectant, Etridiazole.
- Correlation between decrease in intercellular communication and phase I enzyme induction in rat liver treated with phenobarbital : an examination of the reversibility during PB-withdrawal.
- DOES GLUCOSE FEEDING POTENTIATE THE TOXICITY OF HEPATOTOXICANTS?
- Induction of Glutathione S-Transferases and Hepatocellular Proliferating Activities in the Rat Liver Treated with tert-Butylated Hydroxyanisole, 1, 2-Bis(2-Pyridyl)Ethylene, and Phenobarbital
- Circadian modulation of hepatic transcriptome in transgenic rats expressing human growth hormone
- トログリタゾンによる肝障害の機序解明への薬物動態学的アプローチ - UGTの多型は肝障害の要因となり得るか? -
- Acquired Resistance to Bromobenzene Hepatotoxicity by Repeated Treatment of Rats with Bromobenzene
- EFFECT OF TROGLITAZONE ON THE LIVER OF A GUNN RAT MODEL OF GENETIC ENZYME POLYMORPHISM
- Sex difference and effect of growth hormone on daily fluctuation of hepatic P450 monooxygenase activities in rats.
- Comparison of the Induction Profile of Hepatic Drug-metabolizing Enzymes Between Piperonyl Butoxide and Phenobarbital in Rats
- 3A-03 Effect of Adrenalectomy on Daily Fluctuation of Liver Metabolic Enzyme Activities in F344 Rats
- "B-7 Daily fluctuation of liver metabolic enzymes in F344 rats.
- "A-9 Changes of the liver and kidney in rats treated with tert-butylated hydroxyanisole (BHA).
- INVESTIGATION ON RENAL GLUTATHIONE S-TRANSFERASE ACTIVITY OF DOGS : RELATIONSHIP WITH ITS HEPATIC ACTIVITY
- LOW GLUTATHIONE S-TRANSFERASE ACTIVITY IN DOG LIVER AND THE MONITORING METHOD
- SEX DIFFERENCE IN INDUCIBILITY OF LIVER DRUG METABOLIZING ENZYMES IN RATS : In particular emphasis on Phase II enzymes
- NECESSARY PERIOD FOR RE-ENTRAINMENT IN RATS AFTER THE REVERSE OF LIGHT-DARK CYCLE : A METHOD TO DETERMINE CONCENTRATIONS OF A TEST SUBSTANCE IN THE BLOOD
- EFFECTS OF ACETONE(AT) ON HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES IN BEAGLE DOGS
- Collaborative work on evaluation of ovarian toxicity : 8) Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats
- Age-Related Changes in Thyroid Lesions and Function in F344/DuCrj Rats
- EFFECT OF DIFFERENT DOSES OF β-NAPHTHOFLAVONE(BNF) ON THE LOCALIZATION OF CYTOCHROME P-450 ISOZYMES IN THE LIVER LOBULE OF RATS
- 323 AN IMMUNOHISTOCHENICAL STUDY ON THE LOCALIZATIONS OF CHEMICAL-INDUCIBLE CYTOCHRONE P-450 WITHIN THE RAT LIVER
- 102 AGE-RELATED CHANGES IN THE SUSCEPTIBILITY OF MALE F344 RAT LIVER TO PEROXISOME PROLIFERATOR, CLOFIBRIC ACID
- 235 COMPARATIVE STUDY OF HEMOLYTIC ANEMIA INDUCED BY ACETYLPHENYLHYDRAZINE IN SIX KINDS OF ANIMALS : RATS, MARMOSETS, MONKEYS, CATS, DOGS AND GOATS
- 3B-08 Changes in Serum C-Reactive Protein (CRP) in Experimental Gastropathy
- PROLONGATION OF PT AND APTT UNDER EXCESSIVE ANTICOAGULANT IN PLASMA FROM RATS AND DOGS
- 老齢B6C3F1マウスの脳小血管における自然発生鉱物質沈着症
- Metal Response Element-binding Transcription Factor-1 Is Activated by Degradation of Metallothionein
- 肝毒性
- 医薬品開発における毒性評価のバイオマーカー
- Effects of Neonatal Administration of Monosodium Glutamate on Bone in Rats
- ラット甲状腺濾胞上皮細胞に観察された細胞質内水腫の1例(短報)
- 1, 2, 4-Triazoleの3位置換基のラットに対する甲状腺腫誘発作用の比較
- 老齢マウス視床における鉱物質沈着症のX線微小部分析
- O-04 Low NO production in metallothionein-null macrophages in response to endotoxin stimulation(BLOOD, IMMUNE AND ALLERGIC SYSTEM)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Physiological Role of Endogenous Metallothionein in the Immune System(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Mechanism of a Terahertz Optical Kerr Shutter with a Gold Nanoparticle System
- Spectrally-Resolved Four-Wave Mixing Spectroscopy in the Exciton and Biexciton Resonant Region in PbI_2
- Decrease in protein binding and its effect on toxicokinetics (TK)/toxicodynamics (TD) of diclofenac and propranolol in pregnant rats
- Two Metallothioneins in the Fresh-Water Fish, Crucian Carp(Carassius cuvieri) : cDNA Cloning and Assignment of Their Expression Isoforms
- Effect of Metallothionein on Doxorubicin-induced Hepatotoxicity(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Physiological Role of Ascorbic Acid Secretion System in the Stomach (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- 3C-06 Hepatoprotection by zinc and sakuraso-saponin in metallothionein-deficient mice
- 3C-05 Molecular Mechanism of Activation of Mouse Metallothionein-I Promoter by Interleukin-6 and Glucocorticoid
- BINDING OF Cd TO METALLOTHIONEIN IN THE PLACENTA OF Cd-TREATED MOUSE
- Toxicogenomic Biomarkers for Liver Toxicity
- Effect of feeding condition on gene expression analysis using DNA chip.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- APPLICATION OF REPEATED BLOOD COLLECTION TECHNIQUE FROM A TAIL VEIN TO TOXICOKINETIC STUDIES IN THE RAT TREATED ORALLY WITH PHENOBARBITAL
- INFLUENCE OF FEEDING CONDITION ON THE ORAL ACUTE TOXICITY OF DRUG IN RATS
- SPECIES DIFFERENCE IN SUSCEPTIBILITY TO PHORBOL MYRISTATE ACETATE-INDUCED LEUKOPENIA AND LUNG INJURY : RAT VS. DOG
- 309 EFFECT OF CLOFIBRATE ON LIVER PEROXISOMES IN SEVERAL RAT STRAINS
- Gene expression analysis on rat livers treated with L-buthionine (S, R)-sulfoximine : investigation of data compatibility between RG U34A and RAE 230A GeneChips(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Gene expression analysis in rat livers and immune organs treated with isoniazid, phenytoin, hydralazine hydrochloride or chlorpromazine(Proceedings of the 32nd Annual Meeting)
- P6-47 Relationship between hepatic glutathione content and gene expression profile in F344 male rats treated with L-Buthionine(S,R)-sulfoximine(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Gene expressions in F344 rat livers treated with acetaminophen or cycloheximide (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effect of aging on gene expression profile in rat livers treated with phenobarbital or clofibrate (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Osteosarcomas in the Lungs of an ICR Mouse
- RENAL EFFECTS OF 26-WEEK ADMINISTRATION OF OLMESARTAN MEDOXOMIL/HYDROCHLOROTHIAZIDE IN RATS
- Analysis of nephropathy using DNA chip.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Gene Expression Analysis on the Rat Liver Treated with Clofibrate or Phenobarbital.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
- Immunohistochemical Staining Methods for Connexin32 on Formalin-Fixed Paraffin-Embedded Sections
- "C-15 Effect of sodium supplementation on CS-866 repeated-dose toxicity study on rats.
- Biochemical and immunohistochemical studies on constitutional changes of P450 isozymes during postnatal development in rat liver.
- Pulmonary Histiocytic Sarcoma in Two Aged Dogs of a Beagle Colony
- Relationship between hepatocellular apoptosis and Kupffer cell activation in the livers of rats treated with cycloheximide(Proceedings of the 32nd Annual Meeting)
- Toxicogenoimics, Proteomics and Metabonomics(Toxicity Screening Strategy in Early Stage Drug Development : Current Situation and Perspective, Proceedings of the 32nd Annual Meeting)
- Comparison of Age-Related Bone Changes between Mini Rats and Wistar Rats
- "P-28 Study of reversibility in rat bone changes induced by beta-aminopropionitrile or aminoacetonitrile
- 322 RELATION BETWEEN CYTOCHRONE P-450 FAMILIES AND THE INDUCTION PROFILE OF 7-ALKOXYCOUMARIN O-DEALKYLASE ACTIVITIES IN RAT LIVER BY SEVERAL CHEMICALS
- 215 CORRELATION BETWEEN PERIPORTAL NECROSIS AND INDUCTION OF MICROSOMAL ENZYMES AFTER REPEATED ADMINISTRATION OF BUTYLATED HYDROXYTOLUENE(BHT)
- SUBACUTE TOXICOLOGICAL STUDY IN MONKEYS TREATED ORALLY WITH PLAVASTATIN SODIUM FOR 5 WEEKS
- PRELIMINARY DOSE FINDING STUDY FOR SUBACUTE TOXICOLOGICAL STUDY OF PRAVASTATIN SODIUM IN MONKEYS
- Effects of monosodium glutamate pretreament on the rat liver changes by clofibrate administration.
- 324 EFFECTS OF PHENOBARBITAL(PB) AND PARTIAL HEPATECTOMY(PH) ON HEPATIC MICROSOMAL DRUG METABOLIZING ENZYMES IN BEAGLE DOGS
- Isolation and Characterization of an Acidic Xylan from Gobo(Arctium lappa L.)(Food & Nutrition)
- Sex and circadian modulatory effects on rat liver as assessed by transcriptome analyses
- IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. III. ORAL ACUTE TOXICITY AND LOCAL IRRITATION OF MEDIUM CHAIN GLYCERIDE
- Bronchioloalveolar Carcinoma in an Aged Beagle Dog
- Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats
- Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice
- Isolation and Characterization of a Xyloglucan from Gobo (Arctium lappa L.)
- Thirteen-week Intravenous Toxicity Study of a Novel Humanized Anti-Human Death Receptor 5 Monoclonal Antibody, CS-1008, in Cynomolgus Monkeys
- Toxicogenomic Biomarkers for Liver Toxicity
- Induction of Glutathione S-Transferases and Hepatocellular Proliferating Activities in the Rat Liver Treated with tert-Butylated Hydroxyanisole, 1,2-Bis(2-Pyridyl)Ethylene, and Phenobarbital.