IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. III. ORAL ACUTE TOXICITY AND LOCAL IRRITATION OF MEDIUM CHAIN GLYCERIDE
スポンサーリンク
概要
- 論文の詳細を見る
Oral acute toxicity of medium chain glyceride (MCG) was studied in mice and rats. In mice and rats, clinical signs such as irregular respiration, laxity of movement, staggering gait and loss of righting reflex appeared after single oral administration of MCG at a relatively large dose. The LD_<50> values determined in male and female mice were 26.9 and 28.5 ml/kg, and in male and female rats were 27.4 and 26.7 ml/kg, respectively. In order to evaluate the biological safety of MCG suppository of cefmetazole sodium (CMZ), its local irritation on the mucous membrane was studied. Primary eye irritation of MCG suppository of CMZ was studied in rabbits. Although mild irritation was seen in conjunctivae, no remarkable changes were observed in cornea and iris. Furthermore, primary effect of MCG suppository of CMZ on the rectal mucous membrane was studied macro- and micro-scopically. It was observed that remarkable histological changes of rectal mucous membrane by MCG suppository of CMZ were not observed in all animals used.
- 公益社団法人日本薬学会の論文
著者
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Kimura Kunio
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd.
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岡田 隆三
(株)東芝研究開発センター
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OKADA Ryuzo
Product Development Laboratories, Sankyo Co., Ltd.
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Okada Ryuzo
Product Development Laboratories Sankyo Co. Ltd.
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Okada Ryuzo
Faculty Of Engineering Osaka University
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Sekine Minoru
Product Development Laboratories Sankyo Co. Ltd.
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Fukami Masaharu
Biological Research Laboratories Sankyo Co. Ltd.
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Awazu S
Tokyo Coll. Pharmacy Tokyo Jpn
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Awazu Shoji
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Sasahara Kunihiro
Product Development Laboratories Sankyo Co. Ltd.
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Kimura Kunio
Laboratory Animal Science And Toxicology Laboratories
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