PROMOTING MECHANISM BY BILE SALT RELATED TO WATER ABSORPTION IN DRUG RECTAL ABSORPTION
スポンサーリンク
概要
- 論文の詳細を見る
The promoting mechanism by bile salts in rat recatal absorption of antipyrine was studied by the in situ recirculating perfusion. The significant correlation between rectal absorption clearance (CL_<AP>) of antipyrine (AP) and apparent water influx (infulx') was found in the control without promoters, indicating the existence of solvent drag in the AP rectal absorption. Sieving coefficient of AP (b_<AP>), i.e. the slope of the regression line between CL_AP and influx', was 0.6 approximately equal to that in small intestine reported previously. The relation between the promoting effects and solvent drag was further studied, resulting that both CL_<AP> and influx'were significantly enhanced by sodium taurocholate (TC-Na), sodium glycocholate (GC-Na) and sodium cholate (C-Na). Accordingly the promoting effects of bile salts might be due to the increase in solvent drag. However TC-Na did not produce the significant change in b_<AP>. From these results, the enhancing mechanism in the epithelial cell membrane transport was discussed.
- 公益社団法人日本薬学会の論文
著者
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HORIE Toshiharu
Departments of Biopharmaceutice, Graduate School of Pharmaceutical Sciences, Chiba University
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Shiga Masaharu
Department Of Biopharmaceutics Tokyo College Of Pharmacy:pharmaceutical Development Laboratories Mei
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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HIRASAWA TOYOTO
Department of Biopharmaceutics, Tokyo College of Pharmacy
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Hirasawa Toyoto
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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澤山 茂
東京農大 栄養
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Horie Toshiharu
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Chiba University
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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