ALTERATION OF 5-HIAA LEVELS IN FRONTAL CORTEX AND DORSAL RAPHE NUCLEUS IN RATS TREATED WITH COMBINED ADMINISTRATION OF TRYPTOPHAN AND ETHANOL
スポンサーリンク
概要
- 論文の詳細を見る
The present studies sought to investigate the effect of tryptophan alone or coadministration of tryptophan and ethanol on the interaction of central frontal cortex and dorsal raphe nucleus serotonergic functional activities by utilizing in vivo microdialysis. Tryptophan (50mg/kg, i.p.) led to a significant increase in the levels of 5-HIAA, a metabolite of serotonin (5-HT), in the dorsal raphe nucleus, but not in the frontal cortex. Coadministration of tryptophan and ethanol caused very marked increases in 5-hydroxyindoleacetic acid (5-HIAA) levels in both the frontal cortex and the dorsal raphe nucleus, although ethanol (1.25g/kg) did not change 5-HIAA levels in both areas. Moreover, the application of WAY100635 (10μM), 5-HT_<1A> antagonist, into the frontal cortex after coadministration caused a marked increase in 5-HIAA levels in the frontal cortex and a decrease in the levels in the dorsal raphe nucleus, although WAY100635 alone had no effect on these levels. This may suggest that WAY100635-induced increase of 5-HIAA levels in the frontal cortex resulted from negative feedback following the blockade of serotonergic 5-HT_<1A> autoreceptors, and that this increase in 5-HIAA levels decreased 5-HIAA levels in the dorsal raphe nucleus by preventing the activation of dorsal raphe 5-HT_<1A> autoreceptors. WAY100635 into the dorsal raphe nucleus did not significantly change 5-HIAA levels in both areas. This may indicate that the blockade of dorsal raphe 5-HT_<1A> autoreceptors by WAY100635 resulted in unchanged 5-HIAA levels in the frontal cortex. Behavioral sign of teeth-chattering was markedly observed following the coadministration and in combination with WAY100635. These results may suggest that the increased 5-HIAA levels in both areas after coadministration are indicative of the interrelation via activation of serotonergic neurons, and that the increased levels are partly responsible for behavioral activation of rats.
- 2006-08-23
著者
-
HOSHI Katsuji
Department of Clinical Pharmacology, Hokkaido College of Pharmacy
-
Hoshi Katsuji
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
-
Bandoh Tsutomu
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
-
Hayashi Masahiro
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
-
Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
-
SHIRAI Yoshitika
Department of Clinical Pharmacology, Hokkaido College of Pharmacy
-
IWAMASA Kaori
Department of Clinical Pharmacology, Hokkaido College of Pharmacy
-
SHINDOME Naomi
Department of Clinical Pharmacology, Hokkaido College of Pharmacy
-
Iwamasa Kaori
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
-
Shindome Naomi
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
-
Shirai Yoshitika
Department Of Clinical Pharmacology Hokkaido College Of Pharmacy
-
Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
関連論文
- Case of hypereosinophilic syndrome with cutaneous necrotizing vasculitis
- Characteristics of vulvar squamous cell carcinoma in Japanese women
- Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats(Biopharmacy)
- ALTERATION OF 5-HIAA LEVELS IN FRONTAL CORTEX AND DORSAL RAPHE NUCLEUS IN RATS TREATED WITH COMBINED ADMINISTRATION OF TRYPTOPHAN AND ETHANOL
- Genetic analysis of cutaneous squamous cell carcinomas arising from different areas
- Evaluation of Absorbability of Poorly Water-Soluble Drugs : Validity of the Use of Additives
- HISTOPATHOLOGICAL STUDY OF THE EFFECTS OF A SINGLE INTRATRACHEAL INSTILLATION OF SURFACE ACTIVE AGENTS ON LUNG IN RATS
- RELATIONSHIP OF REHABILITATION INTERFARING FACTORS TO PROLONGED PROGNOSIS IN PATIENTS WITH MYOCARDIAL INFARCTION : Exercise Test (I) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Use of an antifungal drug, amphotericin B for isolation of thraustochytrids(METHODS)
- IMPROVEMENT OF POORLY ABSORBABLE DRUG BY INTESTINAL GLUCOSE TRANSPORT SYSTEM
- 移植手術成功には抗酸化物質の併用が必要!
- Effectiveness of Pirotiodecane, Absorption Enhancer, on Nasal Absorption in Rabbits
- Absence of BAT-26 instability in gastric intestinal metaplasia
- Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation
- Incorporation of Exogenous Docosahexaenoic Acid into Triacylglycerols and Polar Lipids of Chlorella vulgaris
- A Technique to Enrich α-tocopherol in Clilorella and Marine Rotifers
- Uptake and Accumulation of Exogenous Docosahexaenoic Acid by Chlorella
- CLINICAL SIGNIFICANCE OF LEFT VENTRICULAR REGIONAL WALL MOTION EVALUATED BY MRI IN PATIENTS WITH OLD MYOCARDIAL INFARCTION : CT, MRI : 53 Annual Scientific Meeting, Japanese Circulation Society
- Occurrence of 5'-Deoxyadenosylcobalamin and Its Physiological Function as the Coenzyme of Methylmalonyl-CoA Mutase in a Marine Eukaryotic Microorganism, Schizochytrium limacinum SR21
- Os Odontoideum With Cerebellar Infarction : A Case Report
- Effect of cultivation methods on nutritional enrichment of euryhaline rotifer Brachionus plicatilis
- Effect of primary cultivation method and population growth phase on nutritional enrichment of euryhaline rotifer Brachionus plicatilis(Asian-Pacific Aquaculture 2007,Abstracts of Conference)
- Rotifers Fed with n-3 Highly Unsaturated Fatty Acid-enriched Chlorella vulgaris are Suitable for the Rearing of Larval Red Sea Bream Pagrus major
- Antioxidative Potential of Fluvastatin via the Inhibition of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase Activity
- Clarification of the Mechanism of Structural Change Induced by Reoxygenation following the Induction of Lipid Peroxidation in Caco-2 Cell Monolayers
- PARACELLULAR CHANNEL CHARACTERIZED BY NON-ELECTROLYTE PERMEATION THROUGH THE COLONIC MEMBRANE OF THE RAT
- MECHANISMS FOR THE ENHANCEMENT OF INTESTINAL MEMBRANE PERMEABILITY BY ABSORPTION PROMOTERS
- Effects of Cold Shock Treatment on Total Lipid Content and Fatty Acid Composition of Aurantiochytrium limacinum strain mh0186
- A Novel Phosphatidylcholine Which Contains Pentadecanoic Acid at sn-1 and Docosahexaenoic Acid at sn-2 in Schizochytrium sp. F26-b
- Changes in the Localization of Ileal P-Glycoprotein Induced by Intestinal Ischemia/Reperfusion
- 肝臓および腎臓における P-glycoprotein に対する小腸虚血再灌流の影響
- Assessment of Ileal Epithelial P-Glycoprotein Dysfunction Induced by Ischemia/Reperfusion using in vivo Animal Model
- Effect of Addition of Tween 80 and Potassium Dihydrogenphosphate to Basal Medium on the Isolation of Marine Eukaryotes, Thraustochytrids(METHODS)
- The Novel Formulation Design of Self-emulsifying Drug Delivery Systems (SEDDS) Type O/W Microemulsion III : The Permeation Mechanism of a Poorly Water Soluble Drug Entrapped O/W Microemulsion in Rat Isolated Intestinal Membrane by the Ussing Chamber Metho
- ALTERATION IN RAT LIVER MICROSOMAL MEMBRANES INDUCED BY ACETAMINOPHEN
- HETEROGENEOUS DISTRIBUTION OF THE CONJUGATION ACTIVITY OF ACETAMINOPHEN AND p-NITROPHENOL IN ISOLATED RAT LIVER CELLS
- MULTIPLE FORMS OF ARYL SULFOTRANSFERASE FOR ACETAMINOPHEN SULFATE CONJUGATION IN RAT LIVER CYTOSOL
- HETEROGENEOUS DISTRIBUTION OF CONJUGATION ACTIVITIES OF HARMOL IN ISOLATED RAT LIVER CELLS
- An autopsied case of Creutzfeldt-Jakob disease with the lateral geniculate body lesion showing antagonizing correlation between periodic synchronous discharges and photically induced giant evoked responses
- Neuropathological comparative study of two patients with Machado-Joseph disease(MJD)
- Linear immunoglobulin A bullous dermatosis associated with herpes simplex virus infection and Kawasaki disease
- Rare case of biphasic tumor of the breast with prominent CD34-positive spindle cells
- Survey of Enhanced, Thermally Stable, and Soluble Second-Order Nonlinear Optical Azo Chromophores
- 酒石酸の新たな役割 : P-glycoprotein 機能修飾
- Regional Difference in P-glycoprotein Function in Rat Intestine
- Optimization of Culture Conditions for Growth and Docosahexaenoic Acid Production by a Marine Thraustochytrid, Aurantiochytrium limacinum mh0186
- Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese men
- Inhibitory Effects of Glibenclamide and Pertussis Toxin on the Attenuation of Ischemia-Induced Myocardial Acidosis Following Ischemic Preconditioning in Dogs
- Mutation analyses of patients with dyschromatosis symmetrica hereditaria : Five novel mutations of the ADAR1 gene
- リン酸輸送担体(NaPi)は腸管におけるリン酸吸収の主役を担っている
- ACTION MECHANISM OF PERMEATION ENHANCERS IN PARACELLULAR PATHWAY
- INTESTINAL ABSORPTION OF MACROMOLECULAR COMPOUNDS-IS ITS IMPROVEMENT POSSIBLE?
- ARYL SULFOTRANSFERASE IN RAT LIVER : MULTIPLICITY AND SUBSTRATE SPECIFICITY
- ALBUMIN-MEDIATED UPTAKE MECHANISM OF DRUG BY ISOLATED HEPATOCYTES
- CHARACTERIZATION OF THE INTERACTION OF ALBUMIN WITH ISOLATED RAT LIVER CELLS TO REVEAL THE MECHANISM OF ALBUMIN-MEDIATED HEPATIC TRANSPORT
- p-NITROPHENOL SULFATION IN RAT LIVER CYTOSOL : MULTIPLE FORMS AND SUBSTRATE INHIBITION OF ARYL SULFOTRANSFERASE
- CORRELATION OF DRUG CONJUGATIVE METABOLISM RATES BETWEEN IN VIVO AND IN VITRO : GLUCURONIDATION AND SULFATION OF p-NITROPHENOL AS A MODEL COMPOUND IN RAT
- CORRELATION BETWEEN IN VIVO AND IN VITRO DRUG CONJUGATIVE METABOLISM RATE : p-NITROPHENOL AS A MODEL COMPOUND
- The Effects of Absorption Enhancers on the Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) in Rats
- Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Intratracheal Administration to Rats
- Hepatic Uptake of Lipid-Soluble Drugs from Fat Emulsion
- ADM-INDUCED LIPID PEROXIDATION IN RAT LIVER AND HEART
- PROTECTION OF RAT SMALL INTESTINE BY VITAMIN A FROM METHOTREXATE-INDUCED DAMAGE : STUDY ON THE NUTRIENT ABSORPTION IN THE SMALL INTESTINE
- Effect of Carrier-Mediated Transport System on Intestinal Fosfomycin Absorption in Situ and in Vivo
- PROTECTION OF RAT SMALL INTESTINE BY VITAMIN A FROM ITS DAMAGE INDUCED BY METHOTREXATE
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION : STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
- Improvement of Drug Release Rate from Carbopol 934P Formulation
- Immunohistochemical study of neuronal intranuclear and cytoplasmic inclusions in Machado-Joseph disease
- Effect of Tween 80 on the growth, lipid accumulation and fatty acid composition of Thraustochytrium aureum ATCC 34304(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- STUDIES OF REPEATED ADMINISTRATION OF FK-506 ON MYOCARDIAL METABOLISM IN RATS
- Effects of Azelnidipine, a Dihydropyridine Calcium Antagonist, on Myocardial Stunning in Dogs
- Lipid Peroxidation in the Pancreas and Other Organs in Streptozotocin Diabetic Rats
- Detection of Genes Involved in Fatty Acid Elongation and Desaturation in Thraustochytrid Marine Eukaryotes
- Effect of Vitamin B12-Enriched Thraustochytrids on the Population Growth of Rotifers
- Extracellular Enzymes Produced by Marine Eukaryotes, Thraustochytrids
- Dermoscopic features in a case of dyschromatosis symmetrica hereditaria
- New Anthocyanins from Purple Pods of Pea (Pisum spp.)
- EFFECTS OF ALPHA BLOCKERS ON BLOOD PRESSURE AND ON THE Ca-CONTRACTURE OF CAT AORTIC STRIPS
- OUABAIN POTENTIATION OF Ca RELEASE FROM FRAGMENTED CARDIAC SARCOPLASMIC RETICULUM
- ACCUMULATION OF 3H-DIGITOXIN IN CNS OF CATS WITH A HYPERSENSITIVITY TO THE DRUG
- DIFFERENCE BETWEEN EFFECTS OF CHLORPROMAZINE AND PERPHENAZINE ON MICROSOMAL PHOSPHOLIPIDS AND ENZYME ACTIVITIES IN RAT LIVER
- Lipopolysaccharide Transport System across Colonic Epithelial Cells in Normal and Infective Rat
- Comparative Study of Flux of FITC-labeled Dextran 4000 on Normal (iso)-and Hyper-osmolarity in Basal Side in Caco-2 Cell Monolayers
- 薬物の腸管膜透過に関する機構論的解析
- Nonlinear Intestinal Absorption of (1→3)-β-D-Glucan Caused by Absorptive and Secretory Transporting System
- Factors Affecting Glucuronidation Activity in Caco-2 Cells
- FACTORS IN BLOOD SIDE INFLUENCING INTESTINAL DRUG ABSORPTION AND METABOLISM
- CHARACTERIZATION OF FLUORESCENT SUBSTANCES IN PEROXIDIZED RAT LIVER MICROSOMAL MEMBRANE
- FLUORESCENT PRODUCTS AND MEMBRANE FLUIDITY IN PEROXIDIZED RAT LIVER MICROSOMES
- DRUG ABSORPTION MECHANISM BY PROMOTERS IN PARACELLULAR AND TRANSCELLULAR ROUTES
- PROMOTING MECHANISM BY BILE SALT RELATED TO WATER ABSORPTION IN DRUG RECTAL ABSORPTION
- DISTRIBUTION AND BINDING OF DRUGS TO MUSCLE TISSUES IN RAT
- SOLVENT DRAG IN JEJUNAL ABSORPTION OF SALICYLIC ACID AND ANTIPYRINE OBTAINED BY IN SITU SINGLE-PASS RERFUSION METHOD IN RAT
- DRUG DISTRIBUTION AND BINDING TO MUSCLE IN RAT
- Species Differences in Oral Bioavailability of Methotrexate between Rats and Monkeys
- CONCLUDING REMARKS : SUMMARY ON ORAL PEPTIDE DELIVERY
- Effect of Aminoguanidine on Ischemia/Reperfusion Injury in Rat Small Intestine
- The Enhancing Mechanism of Capric Acid (C10) from a Suppository on Rectal Drug Absorption through a Paracellular Pathway
- Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
- Acute effect of amitriptyline, phenobarbital or cobaltous chloride on .DELTA.-aminolevulinic acid synthetase, heme oxygenase and microsomal heme content and drug metabolism in rat liver.