The Enhancing Mechanism of Capric Acid (C10) from a Suppository on Rectal Drug Absorption through a Paracellular Pathway
スポンサーリンク
概要
- 論文の詳細を見る
Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats. The optimal concentration of C10 was 13%. C10 administered as a suppository also reduced rectal membrane resistance (R_m), showing that the above enhancing effect was induced by widening the paracellular pathway. Both the enhancing effect on the absorption and the reducing effect on R_m were inhibited by W7,an inhibitor of myosin light chain kinase. These results supported that, as shown in the in vitro Caco-2 cell system, the C10 effect on the paracellular pathway is due to activating the contraction of Ca^<2+>-calmodulin-dependent actin filament.
- 公益社団法人日本薬学会の論文
- 1997-04-15
著者
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Takeshita Kenichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takahashi Hideyuki
Department Of Botany Graduate School Of Science Kyoto University
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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Kaiho Fusao
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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SHIBASAKI Tamayo
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Shibasaki Tamayo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takahashi Hideyuki
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takahashi Hideyuki
Department Of Bacteriology National Institute Of Infectious Diseases
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Takeshita Kenichi
Department of Biological Science, Faculty of Life and Environmental Science, Shimane University
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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