MULTIPLE FORMS OF ARYL SULFOTRANSFERASE FOR ACETAMINOPHEN SULFATE CONJUGATION IN RAT LIVER CYTOSOL
スポンサーリンク
概要
- 論文の詳細を見る
The multiplicity of aryl aulfotransferase (phenol sulfotransferase, PST) in acetaminophen (APAP) sulfate conjugation was studied in rat liver cytosol. The sulfation rate showed the optimal pH of about 9 similar to that in the phenolic monoamine sulfation. And another optimal pH of about 6.4 was found at the higher APAP concentration such as 16 mM, suggesting the existence of the PST multiplicity in the APAP sulfation. The effect of thermal treatment at various temperatures, 37 to 41℃, showed that PST catalyzing the sulfation at the lower APAP concentration (about less than 1 mM) is more thermolabile and has the lower K_m for APAP than at the higher APAP concentration. The APAP sulfation at μM order APAP in the presence of p-nitrophenol (PNP) was shown to be decreased by the substrate inhibition of PNP to PST. Consequently it is considered the sulfation at the lower APAP concentration (μM order) is mainly catalyzed by the thermolabile PST with the lower K_m for APAP, and at the higher APAP concentration the thermostable PST with the higher K_m partially contributes to the sulfation.
- 公益社団法人日本薬学会の論文
著者
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MIZUMA Takashi
Department of Biopharmaceutics, Tokyo College of Pharmacy
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Araya Hiroshi
Department of Chemistry, Tokyo Institute of Technology
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AWAZU Shoji
東京薬科大学薬学部 薬物動態制御学教室
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Araya Hiroshi
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Mizuma Takashi
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Mizuma Takashi
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
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Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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Awazu S
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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