Transport and Recognition of Aminopeptidase-Resistant Cellobiose-Coupled Tyrosylglycylglycine by Intestinal Na^+/Glucose Cotransporter (SGLT1) : Recognition of Suger Conjugates by SGLT1 Is Much Less Restricted than Transport
スポンサーリンク
概要
- 論文の詳細を見る
Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine (CcpTGG) by intestinal Na^+/glucose cotransporter (SGLT1) was examined in rat small intestine. Inhibitory effect of phloridzin (SGLT1 inhibitor) on the CcpTGG transport was extremely low. Concentration dependence of the CcpTGG transport was observed, but the primary component of transport was pasisve diffusion However, CcpTGG significantly inhibited SGLT1-mediated transport, indicating its recognition by SGLT1. Other glucose-conjugates also inhibited SGLT1-mediated transport. These results indicate that recognition of sugar conjugates by SGLT1 is much less restricted than transport, and that it should be relatively easier to design SGLT1 inhibitors than SGLT1-transportable sugar conjugates.
- 公益社団法人日本薬学会の論文
- 1999-08-15
著者
-
SAKAI Norio
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
-
AWAZU Shoji
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science
-
MIZUMA Takashi
Department of Biopharmaceutics, Tokyo College of Pharmacy
-
Awazu Shoji
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
-
Mizuma Takashi
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
-
HAGI Katsura
Department of Biopharmaceutics and Drug Rational Research Center, School of Pharmacy, Tokyo Universi
-
Awazu Shoji
Deparment Of Biopharmaceutics Tokyo College Of Pharmacy
-
Hagi Katsura
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
-
Sakai Norio
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
-
Mizuma Takashi
Department of Applied Chemistry, Faculty of Engineering, Osaka University
関連論文
- The C-Terminal Region of Serotonin Transporter Is Important for Its Trafficking and Glycosylation
- Analysis of the stable levels of messenger RNA derived from different polymorphic alleles in the vitamin D receptor gene
- Fragmentation of Protein Kinase N (PKN) in the Hydrocephalic Rat Brain
- Antiepileptic Effects of Single and Repeated Oral Administrations of S-312-d, a Novel Calcium Channel Antagonist, on Tonic Convulsions in Spontaneously Epileptic Rats
- Electrophysiological Characterization of Nicotine-Induced Excitaiton of Dopaminergic Neurons in the Rat Substantia Nigra
- Perospirone, a Novel Antipsychotic Agent, Hyperpolarizes Rat Dorsal Raphe Neurons via 5-HT_ Receptor
- Involvement of Ca^ Channels in Abnormal Excitability of Hippocampal CA3 Pyramidal Cells in Noda Epileptic Rats
- IV F10 Abnormal excitability of hippocampal CA3 pyramidal neurons involving abnormal Ca2^+ activity in Noda epileptic rats
- Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation
- Sleep disordered breathing in childhood-onset acid maltase deficiency
- Six novel mutations detected in the GALC gene in 17 Japanese patients with Krabbe disease, and new genotype-phenotype correlation
- Novel mutation of gene coding for glial fibrillary acidic protein in a Japanese patient with Alexander disease
- HISTOPATHOLOGICAL STUDY OF THE EFFECTS OF A SINGLE INTRATRACHEAL INSTILLATION OF SURFACE ACTIVE AGENTS ON LUNG IN RATS
- Involvement of Ca^ Channels in Abnormal Excitability of Hippocampal CA3 Pyramidal Cells in Noda Epileptic Rats
- IMPROVEMENT OF POORLY ABSORBABLE DRUG BY INTESTINAL GLUCOSE TRANSPORT SYSTEM
- Effects of D-Fraction, a Polysaccharide from Grifola frondosa on Tumor Growt Involve Activation of NK Cells
- Computational Analysis of Molecular Recognition in DNA Base-Sequence and Groove by Methidium Chloride Using Molecular Mechanics Calculation
- Electrophysiological Characterization of Nicotine-Induced Excitaiton of Dopaminergic Neurons in the Rat Substantia Nigra
- Spatiotemporal Analysis of the Molecular Interaction between PICK1 and PKC
- Electrophysiological Evaluation for Conditions of Preservation of Isolated Human Colon Tissues
- Polarized Transport was Obseved not in Hydrophilic Compounds but in Dextran in Caco-2 Cell Monolayers
- PARACELLULAR CHANNEL CHARACTERIZED BY NON-ELECTROLYTE PERMEATION THROUGH THE COLONIC MEMBRANE OF THE RAT
- MECHANISMS FOR THE ENHANCEMENT OF INTESTINAL MEMBRANE PERMEABILITY BY ABSORPTION PROMOTERS
- ALTERATION IN RAT LIVER MICROSOMAL MEMBRANES INDUCED BY ACETAMINOPHEN
- HETEROGENEOUS DISTRIBUTION OF THE CONJUGATION ACTIVITY OF ACETAMINOPHEN AND p-NITROPHENOL IN ISOLATED RAT LIVER CELLS
- MULTIPLE FORMS OF ARYL SULFOTRANSFERASE FOR ACETAMINOPHEN SULFATE CONJUGATION IN RAT LIVER CYTOSOL
- HETEROGENEOUS DISTRIBUTION OF CONJUGATION ACTIVITIES OF HARMOL IN ISOLATED RAT LIVER CELLS
- Mutational analysis of MECP2 in Japanese patients with atypical Rett syndrome
- Mutation analysis of two Japanese patients with Fanconi-Bickel syndrome
- Pathogenesis of leukodystrophy for Krabbe disease : Molecular mechanism and clinical treatment
- Theoretical Relation between Spatial Resolution and Efficiency of Detection in Scanning Hot Electron Microscope
- Shortening of Detection Time for Observation of Hot Electron Spatial Distribution by Scanning Hot Electron Microscopy
- Transport and Recognition of Aminopeptidase-Resistant Cellobiose-Coupled Tyrosylglycylglycine by Intestinal Na^+/Glucose Cotransporter (SGLT1) : Recognition of Suger Conjugates by SGLT1 Is Much Less Restricted than Transport
- Kinetic Impact of presystemic Intestinal Metabolism on Drug Absorption:Experiment and Date Analysis for the Prediction of In Vivo Absorption from In Vitro Data
- Preference of Peyer's Patches to Jejunal Epithelium for Intestinal Absorption of Oligopeptides, Tyrosylglycylglycine and D-Kyotorphin
- ACTION MECHANISM OF PERMEATION ENHANCERS IN PARACELLULAR PATHWAY
- Photo-Stability of Drugs in Enteral Hyperalimentation Solutions and Its Influence on the Dose Given by a Continuous Infusion
- INTESTINAL ABSORPTION OF MACROMOLECULAR COMPOUNDS-IS ITS IMPROVEMENT POSSIBLE?
- Evaluation of Dose of Unstable Drug Administered by Infusion
- ARYL SULFOTRANSFERASE IN RAT LIVER : MULTIPLICITY AND SUBSTRATE SPECIFICITY
- ALBUMIN-MEDIATED UPTAKE MECHANISM OF DRUG BY ISOLATED HEPATOCYTES
- CHARACTERIZATION OF THE INTERACTION OF ALBUMIN WITH ISOLATED RAT LIVER CELLS TO REVEAL THE MECHANISM OF ALBUMIN-MEDIATED HEPATIC TRANSPORT
- THE EFFECT OF ALBUMIN ON THE UPTAKE OF BROMOSULFOPHTHALEIN BY ISOLATED RAT HEPATOCYTES
- p-NITROPHENOL SULFATION IN RAT LIVER CYTOSOL : MULTIPLE FORMS AND SUBSTRATE INHIBITION OF ARYL SULFOTRANSFERASE
- CORRELATION OF DRUG CONJUGATIVE METABOLISM RATES BETWEEN IN VIVO AND IN VITRO : GLUCURONIDATION AND SULFATION OF p-NITROPHENOL AS A MODEL COMPOUND IN RAT
- Critical Factor in Intestinal Absorption of Peptide Drugs : Quantitative Analysis of Peptide Drug Absorption which is Competitive Process of Metabolism and Transport
- CORRELATION BETWEEN IN VIVO AND IN VITRO DRUG CONJUGATIVE METABOLISM RATE : p-NITROPHENOL AS A MODEL COMPOUND
- The Effects of Absorption Enhancers on the Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) in Rats
- Effect of 2-Methylimidazole on the Mechanical, Biochemical, and Morphological Properties of the Rat Aorta by Its Chronic Treatment along Maturation
- Retention Mechanism of Imidazoles in Connective Tissue. IV. Identification of a Nucleophilic imidazolone Metabolite in Rats
- Retention Mechanism of Imidazoles in Connective Tissue. III. Aldehyde Adduct Formation of a 4(5H)(or 5(4H))-Imidazolone Product in Vitro
- Retention Mechanism of Imidazoles in Connective Tissue. II. Activation of Imidazoles in Cupro-ascorbate System for Irreversible Binding Formation with Aortic Tissue in Vitro
- Report 1 : OUTLINE AND DISCUSSION POINTS OF GUIDANCE FOR REPEATED DOSE TISSUE DISTRIBUTION STUDIES (Repeated dose tissue distribution studies)
- Pulmonary Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Intratracheal Administration to Rats
- Hepatic Uptake of Lipid-Soluble Drugs from Fat Emulsion
- Paracellular and Transcellular Permeabilities of Fosfomycin across Small Intestinal Membrane of Rat and Rabbit by Voltage-Clamp Method
- ADM-INDUCED LIPID PEROXIDATION IN RAT LIVER AND HEART
- PROTECTION OF RAT SMALL INTESTINE BY VITAMIN A FROM METHOTREXATE-INDUCED DAMAGE : STUDY ON THE NUTRIENT ABSORPTION IN THE SMALL INTESTINE
- Effect of Carrier-Mediated Transport System on Intestinal Fosfomycin Absorption in Situ and in Vivo
- PROTECTION OF RAT SMALL INTESTINE BY VITAMIN A FROM ITS DAMAGE INDUCED BY METHOTREXATE
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION : STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
- High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide
- IRREVERSIBLE BINDING OF FUROSEMIDE TO HUMAN SERUM ALBUMIN BY METABOLIC ACTIVATION, PHOTOACTIVATION AND BOTH ACTIVATIONS
- IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. V. EFFECT OF SURFACTANTS ON THE PROMOTING EFFECT OF MEDIUM CHAIN GLYCERIDE FOR THE RECTAL ABSORPTION OF β-LACTAM ANTIBIOTICS IN RATS AND DOGS
- IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. IV. MECHANISM OF THE PROMOTING EFFECT OF MEDIUM CHAIN GLYCERIDE ON THE RECTAL ABSORPTION OF WATER SOLUBLE DRUGS
- IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. III. ORAL ACUTE TOXICITY AND LOCAL IRRITATION OF MEDIUM CHAIN GLYCERIDE
- IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS. II. EFFECT OF MEDIUM CHAIN GLYCERIDE BASE ON THE INTESTINAL ABSORPTION OF CEFMETAZOLE SODIUM IN RATS AND DOGS
- IMPROVEMENT OF BIOAVAILABILITY OF POORLY ABSORBED DRUGS.I.EFFECT OF MEDIUM CHAIN GLYCERIDE BASE ON THE RECTAL ABSORPTION OF CEFMETAZOLE SODIUM IN RATS
- Elucidation of the Molecular Mechanism and Exploration of Novel Therapeutics for Spinocerebellar Ataxia Caused by Mutant Protein Kinase Cγ
- Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation
- Concentration-Dependent Atypical Intestinal Absorption of Cyclic Phenylalanylserine: Small Intestine Acts as an Interface between the Body and Ingested Compounds(Biopharmacy)
- Factors Affecting Glucuronidation Activity in Caco-2 Cells
- FACTORS IN BLOOD SIDE INFLUENCING INTESTINAL DRUG ABSORPTION AND METABOLISM
- CHARACTERIZATION OF FLUORESCENT SUBSTANCES IN PEROXIDIZED RAT LIVER MICROSOMAL MEMBRANE
- FLUORESCENT PRODUCTS AND MEMBRANE FLUIDITY IN PEROXIDIZED RAT LIVER MICROSOMES
- DRUG ABSORPTION MECHANISM BY PROMOTERS IN PARACELLULAR AND TRANSCELLULAR ROUTES
- PROMOTING MECHANISM BY BILE SALT RELATED TO WATER ABSORPTION IN DRUG RECTAL ABSORPTION
- PROTEIN FOR DRUG DISTRIBUTION IN MUSCLE
- DISTRIBUTION AND BINDING OF DRUGS TO MUSCLE TISSUES IN RAT
- SOLVENT DRAG IN JEJUNAL ABSORPTION OF SALICYLIC ACID AND ANTIPYRINE OBTAINED BY IN SITU SINGLE-PASS RERFUSION METHOD IN RAT
- DRUG DISTRIBUTION AND BINDING TO MUSCLE IN RAT
- SOLVENT DRAG EFFECT IN DRUG INTESTINAL ABSORPTION. I. STUDIES ON DRUG AND D_2O ABSORPTION CLEARANCES
- Clinical aspects and adrenal functions in eleven Japanese children with X-linked adrenoleukodystrophy
- Elucidation of the Molecular Mechanism and Exploration of Novel Therapeutics for Spinocerebellar Ataxia Caused by Mutant Protein Kinase Cγ
- SLC2A1 gene analysis of Japanese patients with glucose transporter 1 deficiency syndrome
- Mucolipidosis II and III alpha/beta : mutation analysis of 40 Japanese patients showed genotype-phenotype correlation
- Leukodystrophies (International Review of Child Neurology Series)
- Long-Term Exposure of RN46A Cells Expressing Serotonin Transporter (SERT) to a cAMP Analog Up-regulates SERT Activity and Is Accompanied by Neural Differentiation of the Cells
- Clinicogenetical features of a Japanese patient with giant axonal neuropathy
- Effects of the Chemical Chaperone 4-Phenylbutylate on the Function of the Serotonin Transporter (SERT) Expressed in COS-7 Cells
- Molecular structures of (2)(2,5)(7,7,8,8-tetracyanoquinodimethano)(2)paracyclophane and 14,17-dimethoxy(2)(2,5)(7,7,8,8-tetracyanoquinodimethano)(2)paracyclophane.
- The crystal structure of 2,11,20-trithia(3.3.3)(1,2,4)(1,3,5)cyclophane and molecular structures of unsymmertically tris-bridged (2.2.2)(1,2,4)(1,3,5) and (2.2.2)(1,2,4)(1,2,5)cyclophanes, estimated by molecular conformational analysis.
- Antiepileptic Effects of Single and Repeated Oral Administrations of S-312-d, a Novel Calcium Channel Antagonist, on Tonic Convulsions in Spontaneously Epileptic Rats
- Shortening of Detection Time for Observation of Hot Electron Spatial Distribution by Scanning Hot Electron Microscopy
- Molecular structure of (2)(2,5)(7,7,8,8-tetracyanoquinodimethano)-(2)(1,4)naphtalenophane.
- Long-Term Exposure of RN46A Cells Expressing Serotonin Transporter (SERT) to a cAMP Analog Up-regulates SERT Activity and Is Accompanied by Neural Differentiation of the Cells