Electrophysiological Characterization of Nicotine-Induced Excitaiton of Dopaminergic Neurons in the Rat Substantia Nigra
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概要
- 論文の詳細を見る
The electrophysiological characteristics of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra was investigated using the whole-cell patch clamp technique under the voltage-clamp mode. Nicotine (0.01 – 100 μM) induced inward currents corresponding to nicotine-induced depolarization with an increase in firing in a dose-dependent manner. This current was inhibited by dihydro-β-erythroidine, a selective antagonist for the α4β2 type neuronal nicotinic receptor. Nicotine directly acts on postsynaptic α4β2 type nicotinic receptors and induces inward currents, resulting in excitation of dopaminergic neurons in the substantia nigra and subsequent enhancement of dopamine release in the corpus striatum.
- 社団法人 日本薬理学会の論文
- 2003-10-01
著者
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AMANO Taku
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SEKI Takahiro
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SAKAI Norio
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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斎藤 尚亮
神戸大学・バイオシグナル研究センター
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斎藤 尚亮
神戸大、バイオシグナル研究センター
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Sasa Masashi
Nagisa Clinic, Japan
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Sakai Norio
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Matsubayashi Hiroaki
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Seki T
Tokyo Inst. Technol. Yokohama
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Seki Takahiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Sasa M
Department Of Pharmacology Hiroshima University School Of Medicine
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Amano T
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Pharamacology Hiroshima University School Of Medicine
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Sasa Masashi
Institute Of Laboratory Animals Graduate School Of Medicine Kyoto University
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Seki T
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Seki Takahiro
Chemical Resources Laboratory Tokyo Institute Of Technology
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Seki Takahiro
Photofunctional Chemistry Division Research Laboratory Of Resources Utilization Tokyo Institute Of T
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Seki Takahiro
Department Of Molecular Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Serikawa T
Institute Of Laboratory Animals Kyoto University
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Serikawa Tadao
Inst. Of Lab. Animals Graduate School Of Medicine Kyoto Univ.
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Mukai Hideyuki
Department Of Ophthalmology And Visual Sciences Graduate School Of Biomedical Sciences Hiroshima Uni
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Amano Taku
Department Of Pharmacology Hiroshima University School Of Medicine
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斎藤 尚亮
神戸大学バイオシグナル研究センタｰ分子薬理分野
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Serikawa Tadao
信州大学医学部附属加齢適応研究センター
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Matsubayashi Hiroaki
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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関 隆広
Inst. Of Lab. Animals Graduate School Of Medicine Kyoto Univ.
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Matsubayashi Hiroaki
Department Of Ophthalmology And Visual Sciences Graduate School Of Biomedical Sciences Hiroshima Uni
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Sakai Norio
Department Of Developmental Medicine (pediatrics) D-5 Osaka University Graduate School Of Medicine.
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Seki Takahiro
Department Of Computer Science Tokyo Institute Of Technology:(present Address)ibm Global Service-jap
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Sakai Norio
Department Of Biopharmaceutics And Drug Rational Research Center School Of Pharmacy Tokyo University
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Seki Takahiro
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Sakai Norio
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Sasa Masashi
Nagisa Clinic
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Seki Takahiro
Department Of Applied Physics Nagoya University
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