Excitation of Rat Striatal Large Neurons by Dopamine and/or Glutamate Released From Nerve Terminals via Presynaptic Nicotinic Receptor (α_4β_2 Type) Stimulation
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概要
- 論文の詳細を見る
Previous in vivo experiments using rats anesthetized with chloral hydrate have revealed that nicotine applied iontophoretically increased firing of striatal neurons receiving excitatory dopaminergic input from the substantia nigra, and nicotine-induced firing was inhibited by domperidone, a dopamine D2 antagonist. The results suggest that nicotine increases release of dopamine from the terminals of dopaminergic neurons. Therefore, we performed the present patch clamp study using slice and acutely dissociated preparations of the rat striatum to elucidate the mechanisms underlying the nicotine-induced excitation of striatal neurons. Application of nicotine (100 μM) to large striatal neurons in slice preparations did not produce any effect on the resting membrane potential, but did increase the frequency of miniature postsynaptic potentials (mpps) and action potentials in all 15 neurons tested. The nicotine-induced increase in mpps and action potentials were inhibited during simultaneous application of domperidone; L-glutamic acid diethyl ester hydrochloride, a non-selective glutamate receptor antagonist; and/or dihydro-β-erythroidine, a central nicotinic acetylcholine receptor (α4 β2 type) antagonist. Postsynaptic current was not induced by nicotine applied by U-tube in 96% of acutely dissociated striatal neurons. The present findings suggest that nicotine mainly acts on the presynaptic nicotinic receptors in the nerve terminals to release neurotransmitters such as dopamine and/or glutamate, thereby activating the striatal large neurons.
- 社団法人 日本薬理学会の論文
- 2001-08-01
著者
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AMANO Taku
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Matsubayashi Hiroaki
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Sasa M
Department Of Pharmacology Hiroshima University School Of Medicine
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Amano T
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Pharamacology Hiroshima University School Of Medicine
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Sasa Masashi
Institute Of Laboratory Animals Graduate School Of Medicine Kyoto University
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Mukai Hideyuki
Department Of Ophthalmology And Visual Sciences Graduate School Of Biomedical Sciences Hiroshima Uni
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Amano Hiroko
Department of Respiratory Medicinel, JR Tokyo General Hospital
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Amano Taku
Department Of Pharmacology Hiroshima University School Of Medicine
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Matsubayashi Hiroaki
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Taku
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Amano Hiroko
Department Of Pharmacology Hiroshima University School Of Medicine
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Matsubayashi Hiroaki
Department Of Ophthalmology And Visual Sciences Graduate School Of Biomedical Sciences Hiroshima Uni
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