Inhibition by intravenously administered sodium bicarbonate of neuronal activity in medial vestibular nucleus neurons.
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概要
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The effects of 7% sodium bicarbonate on medial vestibular nucleus (MVN) neurons were examined to elucidate the mechanism underlying its antivertigo action, using α-chloralose-anesthetized cats. Intravenous injection of the drug at 1, 2 and 4 mI/kg every 10 min dose-dependently inhibited rotationand glutamate-induced firing of type I neurons, although a low dose of the drug enhanced firing in a few neurons. However, microiontophoretic application of bicarbonate ions did not inhibit rotation or glutamate-induced firing. After injection of the drug, the P0<SUB>2</SUB> level in arterial blood did not differ from previous levels, but the bicarbonate ion levels dose-dependently increased concomitantly with an increase in pH, as compared with previous levels. These results suggest that the intravenous injection of 7% sodium bicarbonate directly inhibits the neuronal activity of the MVN, although the lower dose may enhance neuronal activity by acting on the peripheral vestibule.
- 公益社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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UJIHARA Hisamitsu
Department of Neuropsychiatry, Kochi Medical School
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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Kawabata Atsuhiko
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Kishimoto Takuzo
Department of Pharmacology, Faculty of Medicine, Kyoto University
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