Effects of Protein Kinase C on the Muscarinic Excitation of Rat Adrenal Chromaffin Cells.
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概要
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The role of protein kinase C (PKC)in the muscarinic excitation of chromaffin cells freshly isolated from rat adrenal medullae was examined by the patch-clamp recording method. Acetylcholine and McN-A-343, a M<SUB>1</SUB>-receptor agonist, depolarized the cell and induced action potentials. Phorbol 12, 13dibutyrate (PDBu), an activator of PKC, increased acetylcholine-induced firing concomitant with a persistent depolarization. Under voltage-clamp recording, both McN-A-343 and PDBu decreased the cesium-sensitive K<SUP>+</SUP> current, which was induced by shifting the membrane potential between -140 mV and -40 mV. These results suggested that the stimulation of muscarinic M<SUB>1</SUB>-receptors by cholinergic drugs activated phospholipase C to degrade phosphoinositide, consequently producing diacylglycerol, and diacylglycerol activates PKC to induce excitation of adrenal chromaffin cells.
- 公益社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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UJIHARA Hisamitsu
Department of Neuropsychiatry, Kochi Medical School
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Sasa Masashi
Department of Pharmacology, Hiroshima University School of Medicine
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Tamura Yutaka
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Takaori Shuji
Shimane Medical University
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Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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