Characterization of N^6-Cyclohexyladenosine-Induced Hypothermia in Syrian Hamsters
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概要
- 論文の詳細を見る
The N6-cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature. CHA microinjection into the anterior hypothalamus (AH) elicited the most marked body temperature (Tb) decrease compared with other regions such as the preoptic area, dorsomedial hypothalamus, posterior hypothalamus, and hippocampus. In contrast, microinjected CHA into the medial septum, ventromedial hypothalamus, and lateral hypothalamus resulted in negligible changes in Tb. These results suggest that CHA-induced hypothermia was probably due to suppression of thermogenesis via the site(s) of CHA action, viz., the AH and medial hypothalamus.
- 社団法人 日本薬理学会の論文
- 2005-03-20
著者
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Suzuki Hiroto
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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TAMURA Yutaka
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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MONDEN Mayuko
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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SHIOMI Hirohito
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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SHINTANI Mitsuteru
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Shiomi H
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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Monden Mayuko
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Shiomi Hirohito
Department Of Pharmacology Faculty Of Pharmacy And Phaqrmaceutical Sciences Fukuyama University
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Shintani Mitsuteru
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tamura Yutaka
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tamura Yutaka
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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