Protective Effect of MKC-231, a Novel High Affinity Choline Uptake Enhancer, on Glutamate Cytotoxicity in Cultured Cortical Neurons
スポンサーリンク
概要
- 論文の詳細を見る
This study was performed to examine the neuroprotective action of 2-(2-oxopyrrolidin-1-yl)-N-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro[2, 3-b]quinolin-4-yl)acetoamide (MKC-231), which enhances choline uptake and acetylcholine release in the central nervous system. Glutamate neurotoxicity was assessed with cortical cultures obtained from fetal rats. Exposure of cultures to MKC-231 for 12 – 24 hr ameliorated glutamate cytotoxicity. MKC-231 reduced cytotoxicity induced by ionomycin, a calcium ionophore, but did not affect the cytotoxicity induced by S-nitrosocysteine, a nitric oxide (NO) donor. These findings suggest that MKC-231 protects against glutamate neurotoxicity by suppressing the NO formation triggered by Ca2+-influx.
- 社団法人 日本薬理学会の論文
著者
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Maeda Takehiko
Department of Pharmacology, Wakayama Medical University
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Akaike A
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
京都大学 薬学研究科生体機能解析学
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Akaike A
Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Akaike Akinori
京都薬科大学 病態生理
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Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Maeda Takehiko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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KANEKO Satoshi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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TAMURA Yutaka
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Kaneko Satoshi
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Maeda T
Division Of Adaptation Physiology Faculty Of Medicine Tottori University
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Kaneko Satoshi
Department Of Dermatology Yokohama Rosai Hospital
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Akaike Akinori
Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Tamura Yutaka
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tamura Yutaka
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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