Beneficial Action of 2,4,4-Trimethyl-3-(15-hydroxypentadecyl)-2-cyclohexen-1-one, a Novel Long-Chain Fatty Alcohol, on Diabetic Hypoalgesia and Neuropathic Hyperalgesia
スポンサーリンク
概要
- 論文の詳細を見る
The effects of 2,4,4-trimethyl-3-(15-hydroxypentadecyl)-2-cyclohexen-1-one (tCFA15) on diabetic hypoalgesia and neuropathic hyperalgesia were examined. Treatments of streptozotocin (STZ)-pretreated mice with tCFA15 (8 – 40 mg/kg, i.p.) for 7 days significantly reversed the depressed inflammatory nociceptive licking response in the formalin test. In addition, similar drug treatments and dosing in 7-day postoperative neuropathic pain model rats (prepared by the method of Bennett and Xie) yielded a similarly favorable outcome by significantly reversing decreased nociceptive thresholds in the paw pressure test. These results suggest that tCFA15 may have the potential to normalize sensory nerve abnormalities induced in experimental diabetes and nerve injury.
- 社団法人 日本薬理学会の論文
- 2006-10-20
著者
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Suzuki Hiroto
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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TAMURA Yutaka
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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YAMADA Masashi
Pharmaceuticals Development Department, Meiji Dairies Corporation
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MONDEN Mayuko
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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KOYAMA Keizo
Pharmaceuticals Department, Developmental Section, Meiji Dairies Corporation
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SHIOMI Hirohito
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Shiomi H
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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Koyama Keizo
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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Monden Mayuko
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Shiomi Hirohito
Department Of Pharmacology Faculty Of Pharmacy And Phaqrmaceutical Sciences Fukuyama University
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Tamura Yutaka
Department Of Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Yamada Masashi
Pharmaceutical Department Meiji Milk Products
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Yamada Masashi
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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Tamura Yutaka
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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