Suppression of Laser-Induced Choroidal Neovascularization by Subconjunctival Injection of 9α-Fluoromedroxyprogesterone Acetate (FMPA), an Anti-angiogenic Agent, in Rats(Pharmacology)

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概要

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• 9α-Fluoromedroxyprogesterone acetate (FMPA) is a synthetic analog of medroxyprogesterone acetate (MPA). FMPA exhibited more potent anti-tumor and anti-angiogenic activities in some assay systems than the parent agent, MPA. Exudative age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). Anecortave acetate, an angiostatic steroid, is clinically efficacious in patients with exudative AMD. Betamethasone is an anti-angiogenic steroid. Therefore, we examined the effects of FMPA, anecortave acetate and betamethasone on laser-induced CNV in rats. Anecortave acetate and betamethasone were included as positive controls. Crypton laser was applied to the fundus in Brown Norway rats. Laser photocoagulations were performed in each eye between the major retinal vessels of the superior retina. Subconjunctival injection of FMPA, anecortave acetate or betamethasone was performed once just after the photocoagulation (on day 0). The incidence of CNV formation was evaluated by fluorescein angiography (FAG) on day 14. On the next day, examination of the retinal function was performed by electro retinogram (ERG). Subconjunctival injection of FMPA at doses of 300, 1000 and 3000μg/eye dose-dependently inhibited the incidence of CNV formation. Significant differences were observed at doses of 1000 and 3000μg/eye of FMPA as compared with the control group. Anecortave acetate and betamethasone significantly inhibited the incidence of CNV formation. FMPA at the doses used in this study did not affect the retinal function in rats, as determined by ERG. FMPA appeared to be effective in a rat model of CNV, so it was demonstrated that FMPA might be useful in the treatment of AMD.

• 公益社団法人日本薬学会の論文
• 2006-12-01

著者

• CHOSHI Tominari

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Suzuki Hiroto

  Pharmaceuticals Department Developmental Section Meiji Dairies Corporation

• Hibino Satoshi

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• SUZUKI Hiroto

  Meiji Dairies Corporation

• MURATA Natsuko

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• YAMAJI Taketo

  Division of Research and Development, Meiji Dairies Corporation

• TSUBOI Hiroshi

  Division of Research and Development, Meiji Dairies Corporation

• UCHIDA Masayuki

  Division of Research and Development, Meiji Dairies Corporation

• YAMADA Masashi

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• OIKAWA Tsutomu

  Faculty of Health and Social Work, Kanagawa University of Human Services

• NOBUHIRO Junko

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Choshi Tominari

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Choshi Tominari

  Fukuyama University Faculty Of Pharmacy And Pharmaceutical Sciences

• Choshi Tominari

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Matsuura Nobuyasu

  Dep. Of Life Sci. Fac. Of Sci. Okayama Univ. Of Sci.

• Yamaji Taketo

  Division Of Research And Development Meiji Dairies Corporation

• Yamaji Taketo

  Research And Development Center Division Of Research And Development Meiji Dailies Corporation

• Hibino Satoshi

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Hibino Satoshi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Oikawa T

  Faculty Of Health And Social Work Kanagawa University Of Human Services

• Murata Natsuko

  Pharmaceuticals Development Department Meiji Dairies Corporation

• Tsuboi Hiroshi

  Division Of Research And Development Meiji Dairies Corporation

• Nobuhiro Junko

  Graduate School Of Pharmacy And Pharmaceutical Sciences Faculty Of Pharmacy And Pharmaceutical Scien

• Yamada Masashi

  Product Res. Licensing And Alliance Management Taiho Pharmaceutical Co. Ltd.

• Murata Natsuko

  Department Of Life Science Faculty Of Science Okayama University Of Science

• Yamada Masashi

  Pharmaceutical Department Meiji Milk Products

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