Cry-Consensus Peptide, a Novel Peptide for Immunotherapy of Japanese Cedar Pollinosis, Induces Th1-Predominant Response in Cry j 1-Sensitized B10.S Mice(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Cry-consensus peptide (CCP) is a newly designed peptide for peptide-based immunotherapy of Japanese cedar pollinosis but its mechanism of efficacy is unknown. We investigated the effect of CCP on Cry j 1-specific Th1/Th2 response in a mice model. Subcutaneous injection of CCP decreased Cry j 1-specific IgE and IgG1 in blood slightly, but the IgG2a level was increased significantly in a dose dependent manner. Splenocytes from these mice were stimulated with Cry j 1 in vitro. This inhibited IL-4, IL-5 and IL-10 secretion significantly, but IFN-γ secretion was increased. In vitro CCP stimulation of splenocytes from Cry j 1-sensitized mice induced more marked Th1-predominancy of cytokine production than native allergen stimulation. Taken together, these data suggest that one of the mechanisms of CCP is dependent on the modulation of the antigen-specific Th1/Th2 response.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
-
Murakami Rika
Research Planning Department Division Of Research And Development Meiji Dairies Corporation
-
Murakami Rika
Research And Development Center Division Of Research And Development Meiji Dailies Corporation
-
Murakami Rika
()
-
TSUNEMATSU Masako
Research and Development Center, Division of Research and Development, Meiji Dailies Corporation
-
YAMAJI Taketo
Research and Development Center, Division of Research and Development, Meiji Dailies Corporation
-
KOZUTSUMI Daisuke
Research and Development Center, Division of Research and Development, Meiji Dailies Corporation
-
KINO Kohsuke
Research and Development Center, Division of Research and Development, Meiji Dailies Corporation
-
YOKOYAMA Minehiko
Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
-
Kozutsumi Daisuke
Research And Development Center Division Of Research And Development Meiji Dailies Corporation
-
Kino Kohsuke
Research And Development Center Division Of Research And Development Meiji Dailies Corporation
-
Kino Kohsuke
Food Science Institute Division Of Research And Development Meiji Dairies Corporation
-
Yamaji Taketo
Research And Development Center Division Of Research And Development Meiji Dailies Corporation
-
Yokoyama Minehiko
Research And Development Section Pharmaceuticals Development Department Meiji Dairies Corporation
-
Tsunematsu Masako
Research And Development Center Division Of Research And Development Meiji Dailies Corporation
関連論文
- A Carbazole Derivative Protects Cells Against Endoplasmic Reticulum (ER) Stress and Glutathione Depletion
- Effect of Cry-consensus Peptide, a Novel Recombinant Peptide for Immunotherapy of Japanese Cedar Pollinosis, on an Experimental Allergic Rhinitis Model in B10.S Mice
- Cry-Consensus Peptide, a Novel Peptide for Immunotherapy of Japanese Cedar Pollinosis, Induces Th1-Predominant Response in Cry j 1-Sensitized B10.S Mice(Pharmacology)
- Efficacy of Dibenzoylmethane Derivatives in Protecting against Endoplasmic Reticulum Stress and Inhibiting Nuclear Factor Kappa B on Dextran Sulfate Sodium Induced Colitis in Mice
- Nuclear Factor κB Inhibition by Dibenzoylmethane Derivatives
- Synthesis and Anti-tumor Activity of a Fluorinated Analog of Medroxyprogesterone Acetate (MPA), 9α-Fluoromedroxyprogesterone Acetate (FMPA)
- SYNTHESIS OF A NEW POTENT ANTI-ANGIOGENIC AGENT, 17α-ACETOXY-9α-FLUORO-6α-METHYLPROGESTERONE
- Suppression of Laser-Induced Choroidal Neovascularization by Subconjunctival Injection of 9α-Fluoromedroxyprogesterone Acetate (FMPA), an Anti-angiogenic Agent, in Rats(Pharmacology)
- Oral Administration of Heat-Killed Lactobacillus gasseri OLL2809 Reduces Cedar Pollen Antigen-Induced Peritoneal Eosinophilia in Mice
- Efficacy of Oral Administration of a Heat-Killed Lactobacillus gasseri OLL2809 on Patients of Japanese Cedar Pollinosis with High Japanese-Cedar Pollen-Specific IgE
- Effects of 4-Ethylamino-2-butynyl(2-cyclohexyl-2-phenyl)glycolate Hydrochloride, a Metabolite of Oxybutynin, on Bladder Specimens and Rhythmic Bladder Contraction in Rats in Comparison With Oxybutynin
- Recognition of T Cell Epitopes Unique to Cha o 2, the Major Allergen in Japanese Cypress Pollen, in Allergic Patients Cross-Reactive to Japanese Cedar and Japanese Cypress Pollen