Synthesis and Anti-tumor Activity of a Fluorinated Analog of Medroxyprogesterone Acetate (MPA), 9α-Fluoromedroxyprogesterone Acetate (FMPA)
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概要
- 論文の詳細を見る
We synthesized 9α-fluoromedroxyprogesterone acetate (FMPA) in order to test whether it is a more potent anti-angiogenic agent than medroxyprogesterone acetate (MPA), which has been widely used as a therapeutic agent for breast and endometrium cancers. FMPA was previously synthesized in 10 steps (total yield: 1%). An efficient synthesis of FMPA has been achieved in 6 steps (total yield: 12%). We examined the anti-tumor effect of FMPA, complexed with dimethyl-β-cyclodextrin (DM-β-CyD), on rat mammary carcinomas induced by 7,12-dimethylbenz [a] anthracene (DMBA). FMPA showed great anti-tumor effect on DMBA-induced rat mammary carcinomas.
- 公益社団法人日本薬学会の論文
- 2006-11-01
著者
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佐藤 美洋
北海道大学大学院薬学研究院
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関川 善夫
Department Of Pharmaceutical Sciences National Institute Of Public Health
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Sato Y
Osaka Prefecture University
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CHOSHI Tominari
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Suzuki Hiroto
Pharmaceuticals Department Developmental Section Meiji Dairies Corporation
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Nemoto Hideo
Faculty Of Pharmaceutical Sciences University Of Toyama
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Sato Y
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Sato Y
Kyoritsu College Of Pharmacy
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Hibino Satoshi
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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SUZUKI Hiroto
Meiji Dairies Corporation
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MURATA Natsuko
Pharmaceuticals Development Department, Meiji Dairies Corporation
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FUJIMORI Shiho
Pharmaceuticals Development Department, Meiji Dairies Corporation
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ICHIHARA Yoshitatsu
Pharmaceuticals Development Department, Meiji Dairies Corporation
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SATO Yoshio
Division of Research and Development, Meiji Dairies Corporation
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YAMAJI Taketo
Division of Research and Development, Meiji Dairies Corporation
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TSUBOI Hiroshi
Division of Research and Development, Meiji Dairies Corporation
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UCHIDA Masayuki
Division of Research and Development, Meiji Dairies Corporation
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YAMADA Masashi
Pharmaceuticals Development Department, Meiji Dairies Corporation
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OIKAWA Tsutomu
Faculty of Health and Social Work, Kanagawa University of Human Services
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NOBUHIRO Junko
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Choshi Tominari
Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
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Choshi Tominari
Fukuyama University Faculty Of Pharmacy And Pharmaceutical Sciences
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Choshi Tominari
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Matsuura Nobuyasu
Dep. Of Life Sci. Fac. Of Sci. Okayama Univ. Of Sci.
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佐藤 嘉信
Department Of Chemical Engineering University Of Osaka Prefecture
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Yamaji Taketo
Division Of Research And Development Meiji Dairies Corporation
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Yamaji Taketo
Research And Development Center Division Of Research And Development Meiji Dailies Corporation
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Hibino Satoshi
Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
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Hibino Satoshi
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Fujimori S
Pharmaceuticals Development Department Meiji Dairies Corporation
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Oikawa T
Faculty Of Health And Social Work Kanagawa University Of Human Services
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Murata Natsuko
Pharmaceuticals Development Department Meiji Dairies Corporation
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Tsuboi Hiroshi
Division Of Research And Development Meiji Dairies Corporation
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Nobuhiro Junko
Graduate School Of Pharmacy And Pharmaceutical Sciences Faculty Of Pharmacy And Pharmaceutical Scien
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Iitaka Y
Pharmaceuticals Development Department Meiji Dairies Corporation
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Yamada Masashi
Product Res. Licensing And Alliance Management Taiho Pharmaceutical Co. Ltd.
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Nemoto Hideo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Murata Natsuko
Department Of Life Science Faculty Of Science Okayama University Of Science
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Nemoto Hideo
Fac. Of Pharmaceutical Sciences Univ. Of Toyama
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Yamada Masashi
Pharmaceutical Department Meiji Milk Products
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