Synthesis and Anti-tumor Activity of a Fluorinated Analog of Medroxyprogesterone Acetate (MPA), 9α-Fluoromedroxyprogesterone Acetate (FMPA)

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概要

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• We synthesized 9α-fluoromedroxyprogesterone acetate (FMPA) in order to test whether it is a more potent anti-angiogenic agent than medroxyprogesterone acetate (MPA), which has been widely used as a therapeutic agent for breast and endometrium cancers. FMPA was previously synthesized in 10 steps (total yield: 1%). An efficient synthesis of FMPA has been achieved in 6 steps (total yield: 12%). We examined the anti-tumor effect of FMPA, complexed with dimethyl-β-cyclodextrin (DM-β-CyD), on rat mammary carcinomas induced by 7,12-dimethylbenz [a] anthracene (DMBA). FMPA showed great anti-tumor effect on DMBA-induced rat mammary carcinomas.

• 公益社団法人日本薬学会の論文
• 2006-11-01

著者

• 佐藤 美洋

  北海道大学大学院薬学研究院

• 関川 善夫

  Department Of Pharmaceutical Sciences National Institute Of Public Health

• Sato Y

  Osaka Prefecture University

• CHOSHI Tominari

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Suzuki Hiroto

  Pharmaceuticals Department Developmental Section Meiji Dairies Corporation

• Nemoto Hideo

  Faculty Of Pharmaceutical Sciences University Of Toyama

• Sato Y

  (present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Sato Y

  Kyoritsu College Of Pharmacy

• Hibino Satoshi

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• SUZUKI Hiroto

  Meiji Dairies Corporation

• MURATA Natsuko

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• FUJIMORI Shiho

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• ICHIHARA Yoshitatsu

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• SATO Yoshio

  Division of Research and Development, Meiji Dairies Corporation

• YAMAJI Taketo

  Division of Research and Development, Meiji Dairies Corporation

• TSUBOI Hiroshi

  Division of Research and Development, Meiji Dairies Corporation

• UCHIDA Masayuki

  Division of Research and Development, Meiji Dairies Corporation

• YAMADA Masashi

  Pharmaceuticals Development Department, Meiji Dairies Corporation

• OIKAWA Tsutomu

  Faculty of Health and Social Work, Kanagawa University of Human Services

• NOBUHIRO Junko

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Choshi Tominari

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Choshi Tominari

  Fukuyama University Faculty Of Pharmacy And Pharmaceutical Sciences

• Choshi Tominari

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Matsuura Nobuyasu

  Dep. Of Life Sci. Fac. Of Sci. Okayama Univ. Of Sci.

• 佐藤 嘉信

  Department Of Chemical Engineering University Of Osaka Prefecture

• Yamaji Taketo

  Division Of Research And Development Meiji Dairies Corporation

• Yamaji Taketo

  Research And Development Center Division Of Research And Development Meiji Dailies Corporation

• Hibino Satoshi

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Hibino Satoshi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Fujimori S

  Pharmaceuticals Development Department Meiji Dairies Corporation

• Oikawa T

  Faculty Of Health And Social Work Kanagawa University Of Human Services

• Murata Natsuko

  Pharmaceuticals Development Department Meiji Dairies Corporation

• Tsuboi Hiroshi

  Division Of Research And Development Meiji Dairies Corporation

• Nobuhiro Junko

  Graduate School Of Pharmacy And Pharmaceutical Sciences Faculty Of Pharmacy And Pharmaceutical Scien

• Iitaka Y

  Pharmaceuticals Development Department Meiji Dairies Corporation

• Yamada Masashi

  Product Res. Licensing And Alliance Management Taiho Pharmaceutical Co. Ltd.

• Nemoto Hideo

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Murata Natsuko

  Department Of Life Science Faculty Of Science Okayama University Of Science

• Nemoto Hideo

  Fac. Of Pharmaceutical Sciences Univ. Of Toyama

• Yamada Masashi

  Pharmaceutical Department Meiji Milk Products

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