Reaction of N, N-Dialkyl-N-(trimethylsilyl)methyl-γ-substituted Allylammonium Salts with Cesium Fluoride

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概要

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• The reaction of N, N-dialkyl-N-(trimethylsilyl)methyl-γ-(methoxycarbonyl or cyano)allylammonium salts (1e, g, h) with cesium fluoride in N, N-dimethylformamide (DMF) did not form the expected allyl rearrangement products 3 of N-methylides 2,and instead gave N, N-dialkyl-3-(methoxycarbonyl or cyano)-2-(fluoromethyl)propylamines (9e, g, h) as the main product. The reaction mechanism is discussed.

• 公益社団法人日本薬学会の論文
• 1998-04-15

著者

• 佐藤 美洋

  北海道大学大学院薬学研究院

• 関川 善夫

  Department Of Pharmaceutical Sciences National Institute Of Public Health

• Sato Y

  Osaka Prefecture University

• Sato Y

  (present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• MAEDA Yoshiko

  Showa Pharmaceutical University

• ZHANG Chen

  Faculty of Pharmaceutical Sciences, Nagoya City University

• MAEDA Yasuhiro

  Faculty of Pharmaceutical Sciences, Nagoya City University

• SATO Yoshiro

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Maeda Y

  Showa Pharmaceutical University

• Sato Y

  Kyoritsu College Of Pharmacy

• 佐藤 嘉信

  Department Of Chemical Engineering University Of Osaka Prefecture

• Maeda Yasuhiro

  Faculty Of Engineering Osaka Prefecture University

• Zhang Chen

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Sato Yoshiro

  Faculty Of Pharmaceutical Science Nagoya City University

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