In Vitro Effects of Oxygenated Lanosterol Derivatives on Cholesterol Biosynthesis from 24,25-Dihydrolanosterol
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概要
- 論文の詳細を見る
The effects of oxygenated lanosterol derivatives (1-27,5μM) including 32-oxygenated lanosterol derivatives on cholesterol biosyntheiss from [24,25-^3H_2]-24,25-dihydrolanosterol (18μM) were tested in 10000×g supernatant (S-10) fraction of rat liver homogenate. Among the derivatives, 7-oxolanost-8-en-3β-ol (7-oxo-DHL), 3β-acetoxylanost-8-en-7-one (7-oxo-DHL-3-OAc), and 7-oxolanosta-5,8,11-trien-3β-ol were highly active in depression cholesterol biosynthesis from 24,25-dyhydrolanosterol. The inhibitory activities of these derivatives on cholesterol synthesis are discussed on the basis of the position and stereochemistry of the oxygen functional groups on the sterol nucleus. The effect of aphidicolin on cholesterol synthesis was also compared with that of 7-oxo-DHL.
- 公益社団法人日本薬学会の論文
- 1988-03-25
著者
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佐藤 美洋
北海道大学大学院薬学研究院
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佐藤 良博
共立薬科大学名誉
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園田 よし子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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関川 善夫
Department Of Pharmaceutical Sciences National Institute Of Public Health
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Sato Y
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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関川 善夫
Kyoritsu College of Pharmacy
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佐藤 嘉信
Department Of Chemical Engineering University Of Osaka Prefecture
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