Synthesis of Lanosterol Analogs with Modified Side Chains
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概要
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Starting from lanosteryl acetate (1b), we synthesized twelve lanosterol analogs (cf. Chart 1-3 ; 9,11,14,16,18a, 19,26,27a, 28,29,30,32) with different sizes of side chain and 20-iso-24-dihydrolanosterol (37), for biological studies. The analogs have shorter side chains than 1b except for the 24-ethylidene derivative (19) and 37. 20-Iso-24-di-hydrolanosterol (37) was prepared via 20-iso-22-dehydro-24-dihydrolanosterol [obtained by the Wittig reaction of 20R, S-aldehyde mixture (6,33) with isoamyl triphenylphosphonium iodide, followed by column chromatographic separation].
- 公益社団法人日本薬学会の論文
- 1981-02-25
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