Stereospecific Incorporation of Hydrogen from Reduced Nicotinamide Adenine Dinucleotide Phosphate in Hydrogenation of (-)-Dehydrogriseofulvin to (+)-Griseofulvin by a Partially Purified Enzyme System of Streptomyces cinereocrocatus
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The stereochemistry of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent hydrogenation was investigated by the conversion of (-)-dehydrogriseofulvin (1) to (+)-griseofulvin (2a) by the use of a partially purified enzyme system of Streptomyces cinereocrocatus in the presence of (4R)- or (4S)-[4-^2H_1]NADPH. The results of 270MHz proton nuclear magnetic resonance spectroscopy indicated that the origin of the 6'α-hydrogen of 2a is a hydride ion donated by pro-4R-hydrogen of NADPH.
- 公益社団法人日本薬学会の論文
- 1986-11-25
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