Synthesis of (22R)- and (22S)-22-Hydroxylanosterols
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概要
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Epoxidation of (22E)-3β-acetoxylanosta-8,22-dien-24-one (1) afforded the 22,23-epoxides (2) which were led to (22R)-22-hydroxylanosterol (7a) predominantly and (22S)-22-hydroxylanosterol (8a) as a minor product in a few steps. The epimeric relationship of 7a and 8a was confirmed by Jones oxidation of 7a t) give the 3,22-diketo compound (9), which furnished mainly (22S)-22-hydroxylanosterol (8a) on hydride reduction.
- 公益社団法人日本薬学会の論文
- 1983-03-25
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