Evidence of Intercalation of trans-Diethylstillbestrol and Its Methyl Ether Derivatives in Multibilayers of Egg Phosphatidylcholine by High-Power Deuterium Nuclear Magnetic Resonance (^2H-NMR) Spectroscopy
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概要
- 論文の詳細を見る
The mode of incorporation of ^2H-labeled trans-diethylstilbestrol (DES) (1b) and its methyl ether derivatives (2a, 2b, and 3) into multibilayers of egg phosphatidylcholine was analyzed by means of deuterium nuclear magnetic resonance. A clear distinction was found between DES or its methyl ether derivatives incorporated into lipid bilayers and those precipitated in the aqueous phase, by taking into account the extent of the motionally averaged quadrupole interaction. Thus, it was found that the relative proportion of these compounds incorporated into multibilayers decreased in the following order : DES (1b)>DES monomethyl ether (2a and 2b)>DES dimethyl ether (3). In addition, we demonstrated that the mode of intercalation in the multibilayers differs greatly among these compounds.
- 社団法人日本薬学会の論文
- 1990-09-25
著者
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佐藤 良博
共立薬科大学名誉
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小田 泰子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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斉藤 肇
Biophysics Division National Cancer Center Research Institute
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佐藤 良博
共立薬大
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児玉 晶彦
Biophysics Division, National Cancer Center Research Institute
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児玉 晶彦
Biophysics Division National Cancer Center Research Institute
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