Stereochemistry of Hydrogenation of (-)-Dehydrogriseofulvin to (+)-Griseofulvin with a Cell-Free System of Streptomyces cinereocrocatus
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To elucidate the stereochemistry of the hydrogenation of (-)-dehydrogriseofulvin (1a) to (+)-griseofulvin (3a) by Streptomyces cinereocrocatus, we have prepared from the microorganism a cell-free system which can transform 1a to 3a. The hydrogenation activity of the cell-free system increased in the presence of added reduced nicotinamide adenine dinucleotide phosphate (NADPH). The stereochemistry of hydrogenation was determined by 400 MHz proton nuclear magnetic resonance (^1H-NMR) analysis of the products obtained by the enzymatic conversion of (-)-[5'-^2H]-dehydrogriseofulvin (1b) and also by the enzymatic conversion of 1a in medium containing deuterium oxide.
- 公益社団法人日本薬学会の論文
- 1985-03-25
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