Optically Active trans-Diethylstilbestrol Oxide Monomethyl Ether
スポンサーリンク
概要
- 論文の詳細を見る
Dietylstilbestrol oxide is a metabolic intermediate of diethylstilbestrol. In order to elucidate the effects of optically active diethylstilbestrol oxides on microtubule assembly and cell culture, we synthesized (±)-diethylstilbestrol oxide(2a). Since 2a was not stable under moderately acidic and basic conditions, the monomethyl ether (2c) of diethylstilbestrol oxide, which was more stable than 2a, was separated by high-pressure liquid chromatography using a chiral column.The mono (4-bromobenzoate) of (-)-2c was analyzed by X-ray crystallography and its absolute structure was determined as C (1R, 1'R).
- 公益社団法人日本薬学会の論文
- 1993-05-15
著者
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佐藤 美洋
北海道大学大学院薬学研究院
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佐藤 良博
共立薬科大学名誉
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小田 泰子
Kyoritsu College of Pharmacy
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畠 忠
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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佐藤 良博
Kyoritsu College of Pharmacy
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Sato Y
Osaka Prefecture University
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Sato Y
(present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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綿貫 充
Kyoritsu College of Pharmacy
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畠 忠
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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佐藤 嘉信
Department Of Chemical Engineering University Of Osaka Prefecture
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