Scale-Up of High Shear Granulation Based on Agitation Power

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概要

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• Scale-up of wet granulation in a vertical high shear mixer was conducted. Pharmaceutical excipient mixtures composed of lactose, cornstarch and micro-crystalline cellulose, and hydroxypropylecellulose as a binder were mixed together and then granulated with purified water under various operating conditions and vessel scales. Torque of agitator shaft was continuously measured and then agitation power per unit vessel volume was calculated. The agitation power per unit vessel volume showed a good correlation with physical properties of obtained granules, such as mass median diameter, strength and compressibility. This implied that the scale-up characteristics could be well analyzed by means of the agitation power per unit vessel volume. In addition, the effects of agitator tip speed and Froude number on the agitation power per unit vessel volume were investigated. The results showed that the agitation power per unit vessel volume was well characterized by the tip speed rather than the Froude number. This meant that the granule growth mainly progressed by the shear stress from the agitator blade. Dynamic characteristics of high shear granulation were also discussed here.

• 公益社団法人日本薬学会の論文
• 2005-12-01

著者

• 佐藤 美洋

  北海道大学大学院薬学研究院

• 関川 善夫

  Department Of Pharmaceutical Sciences National Institute Of Public Health

• Sato Y

  Osaka Prefecture University

• Watano S

  Osaka Prefecture University

• Watano Satoru

  Department Of Chemical Engineering Osaka Prefecture University

• Sato Y

  (present Address)tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Sato Y

  Kyoritsu College Of Pharmacy

• SATO YOSHINOBU

  Osaka University

• OKAMOTO Takumi

  Osaka Prefecture University

• WATANO Satoru

  Osaka Prefecture University

• 佐藤 嘉信

  Department Of Chemical Engineering University Of Osaka Prefecture

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