On-line Monitoring of Granule Growth in High Shear Granulation by an Image Processing System

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概要

• 論文の詳細を見る

• A novel system has been developed to continuously monitor granule growth in a high shear granulation. The system consists of an image processing system and a particle image probe comprising a CCD camera, lighting unit and air purge system. Segregation during powder mixing was investigated experimentally and the optimal positioning of the probe was determined.High shear granulation was conducted using pharmaceutical powders, and granule size and product's yield of various size ranges were continuously measured by the developed system. Sieve analysis of the granulated products sampled out during the granulation was simultaneously conducted, and the obtained data was compared with that by the on-line image processing system. An extremely close relationship could be found between both data, proving that the developed system could monitor the granule growth accurately and continuously throughout the granulation. An on-off control system was developed to control the granulation process, and the performance of the system was confirmed.

• 公益社団法人日本薬学会の論文
• 2000-08-01

著者

• Watano S

  Osaka Prefecture University

• Watano Satoru

  Department Of Chemical Engineering Osaka Prefecture University

• Ohnishi Yasuharu

  Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica

• WATANO Satoru

  Osaka Prefecture University

• OSAKO Yoshifumi

  Fuji Paudal Co., Ltd.

• MIYANAMI KEI

  Department of Chemical Engineering, Osaka Prefecture University

• Miyanami K

  Department Of Chemical Engineering Osaka Prefecture University

• Ohnishi Y

  Pharmaceutical Research Lab. Taiho Pharmaceutical Co. Ltd.

• NUMA Tetsuya

  Osaka Prefecture University

• MIYANAMI Kei

  Osaka Prefecture University

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