HPLC Analysis of Juzen-taiho-to and Its Variant Formulations and Their Antimetastatic Efficacies
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概要
- 論文の詳細を見る
Our previous study demonstrated that the oral administration of Juzen-taiho-to resulted in a significant inhibition of the liver metastasis of colon 26-L5 cells as compared with the untreated control, without side effects. We attempted to investigate the relationship between the HPLC pattern (referred to as the fingerprint) of the formulation and its component crude drugs and the inhibition of tumor metastasis in order to obtain the optimal efficacy and constant quality of the formulation. Two Juzen-taiho-to formulations (batches #1 and #2), which were individually prepared using the same 10 crude drugs and the same preparation procedure, showed similar anti-metastatic effects and absorbance patterns by HPLC analysis. Some variant formulations of Juzen-taiho-to, in which one crude drug was substituted with other crude drugs from different sources or places of origin, exhibited reduced efficacy as compared with the original formulation, as well as differences in the fingerprint pttern compared with the original formulation. Juzen (Naimo-Ogi→Kibana-Ogi), a variant formulation with the substitution of Astragali radix of a different origin and place of harvest, showed significant inhibition of the liver metastasis of tumor cells and a HPLC fingerprint pattern similar to that of the original formulation. Thus, HPLC fingerprint analysis of Kampo medicines may provide a useful basis for obtaining their optimal efficacy as well as constant quality of the formulation, although it has some problems and limitations, such as detectability by and sensitivity to UV absorbance.
- 社団法人日本薬学会の論文
- 1999-08-15
著者
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SAIKI Ikuo
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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HAYAKAWA Yoshihiro
Department of Pathogenic Biochemistry, Institute of Natural Medicine
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NUNOME Shinyu
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.
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YAMAURA Takeshi
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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OHNISHI Yasuharu
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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KOMATSU Yasuhiro
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.,
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Yamaura Takeshi
富山医科薬科大学和漢薬研究所
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Yamaura T
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Yamaura Takeshi
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Komatsu Yasuhiro
北陸大学 薬 薬物治療
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Hayakawa Yoshihiro
富山医科薬科大学 和漢診療
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Hayakawa Y
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Nunome Shinyu
Kampo And Pharmacognosy Laboratory Tsumura Central Laboratories Tsumura & Co.
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Nunome Shinyu
Kampo And Pharmacognosy Laboratory Tsumura & Co.
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Komatsu Y
Tsumura Central Research Laboratories Tsumura And Co.
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Komatsu Y
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Komatsu Yasuhiro
Department Of Serology Kanazawa Medical University
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Ohnishi Yasuharu
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Yamaura Takeshi
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Komatsu Y
National Institute Of Advanced Industrial Science And Technology
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Komatsu Y
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Ohnishi Y
Pharmaceutical Research Lab. Taiho Pharmaceutical Co. Ltd.
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Hayakawa Yoshihiro
Department Of Pathogenic Biochemistry Institute Of Natural Medicine
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Komatsu Y
Res. Center Eishogen Co. Ltd. Saitama Jpn
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Komatsu Yasuhiro
Kampo & Pharmacognosy Laboratory Tsumura & Co.
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine
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Hayakawa Yoshihiro
Department of Chemistry, Faculty of Science, Nagoya University
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