Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
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概要
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The original publication is available at www.springerlink.comBackground: Hepatoprotective therapies that include regular glycyrrhizin injection (GI) are beneficial for chronic hepatitis C patients, but are sometimes unable to normalize serum alanine aminotransferase (ALT) levels. Here, we evaluated whether the addition of minor bloodletting, named petit phlebotomy (PP), prior to each GI could further reduce serum ALT concentrations in such patients.Methods: Seventy-six HCV-infected patients receiving regular GI with persistently abnormal serum ALT levels were randomly divided into GI+PP or GI groups and monitored for 12 months. PP was performed before every GI to a total 60 ml of blood a week. The primary PP endpoint was serum ferritin levels of less than 20 ng/ml. PP was suspended upon reaching the endpoint, but was resumed as needed. The efficacy of the addition of PP was evaluated by measuring changes in serum ALT levels.Results: Two patients in each group dropped out because of apparition of hepatocellular carcinoma. The remainder completed the 12-month treatment with no serious adverse events. Serum ALT and ferritin levels were significantly decreased in the GI+PP group (from 67 + 34 to 44 + 14 U/l and from 163 + 127 to 25 + 21 ng/ml, respectively, both P<0.001), but these changes were not seen in the GI group. Although twenty patients in the GI+PP group had compensated cirrhosis, no significant reductions in serum albumin concentrations were observed.Conclusions: The addition of PP is effective and safe for improving serum aminotransferase levels in HCV-infected patients receiving regular GI, even in those with compensated cirrhosis.
- Springer Japanの論文
- 2009-06-01
著者
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TANAKA Eiji
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate Sch
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AOYAMA Toshifumi
Department of Metabolic Regulation, Institute of Aging and Adaptation, Shinshu University Graduate S
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Yamaura T
Department Pathogenic Biochemistry Institue Of Natural Medicine
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Tanaka Naoki
Department of Gastroenterology, Shinshu University School of Medicine
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Komatsu Michiharu
信州大学 医学部内科学
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Komatsu Michiharu
Division Of Gastroenterology Department Of Internal Medicine Shinshu University School Of Medicine
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Tanaka Eiji
Shinshu Univ. School Of Medicine Matsumoto Jpn
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Tanaka Eiji
Department Of Digestion And Cardiovascular Medicine University Of Tokushima
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Takeda Naokazu
Department Of Gastroenterology Shinshu University School Of Medicine
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Tanaka N
Department Of Applied Biological Sciences Faculty Of Agriculture Saga University
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Kiyosawa Kendo
Department Of Internal Medicine Nagano Red Cross Hospital
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Kiyosawa Kendo
Department Of Gastroenterology Shinshu University School Of Medicine
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Kitano Kiyoshi
Second Department Of Internal Medicine Shinshu University Medical School
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Nagaya T
Department Of Endocrinology And Metabolism Division Of Molecular And Cellular Adaptation Institution
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Tanaka Naoki
信州大学 保健学科循環器内科
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OKANIWA Shinji
Department of Gastroenterology, Sendai City Medical Center
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HORIUCHI Akira
Department of Pharmacology, Shinshu University School of Medicine
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YAMAURA Takahiro
Department of Electrical and Electronic Engineering and Photon Science Center
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Yoshizawa Kaname
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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Komatsu Michiharu
Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Me
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YOKOYAMA Takahide
Department of Surgery, Shinshu University School of Medicine
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NAGAYA Tadanobu
Department of Gastroenterology, Shinshu University School of Medicine
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Horiuchi Akira
Department Of Chemistry Rikkyo (st. Paul's) University
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Aoyama T
Department Of Experimental Radiology Shiga University Of Medical Science
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Okaniwa Shinji
Department Of Gastroenterology Iida Municipal Hospital
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Kiyosawa Kendo
Department Of Internal Medicine School Of Medicine Shinshu University
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Tanaka E
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Yoshizawa Kaname
Department Of Gastroenterology Shinshu University School Of Medicine
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Kiyosawa K
Department Of Gastroenterology Shinshu University School Of Medicine
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Horiuchi A
Department Of Obstetrics And Gynecology Shinshu University School Of Medicine
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Horiuchi Akira
Department Of Gastroenterology Showa Inan General Hospital
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Yokoyama T
Department Of Applied Physics National Defense Academy
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Aoyama Toshifumi
Department Of Metabolic Regulation Shinshu University Graduate School Of Medicine
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Aoyama Toshifumi
Department Of Biochemistry Shinshu University
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Yamaura Takahiro
Department Of Gastroenterology Iida Municipal Hospital
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Yoshizawa K
Department Of Aging Medicine And Geriatrics Shinshu University Graduate School Of Medicine
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Komatsu M
Department Of Applied Chemistry Faculty Of Engineering Kyushu University
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Nagaya Tadanobu
Department Of Gastroenterology Shinshu University School Of Medicine
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Komatsu Michiharu
Department Of Gastroenterology Shinshu University School Of Medicine
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Tanaka Eiji
Division Of Gastroenterology Department Of Internal Medicine Shinshu University School Of Medicine
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Kobayashi Masakazu
Department Of Gastroenterology Shinshu University School Of Medicine
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Tanaka Naoki
Department Of Electronical And Computer Engineering Kumamoto University
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Tanaka Naoki
Department Of Bio-molecular Engineering Kyoto Institute Of Technology
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Tanaka E
Department Of Medicine Shinshu University School Of Medicine
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Okaniwa S
Department of Gastroenterology, Iida Municipal Hospital
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Yamaura T
Department of Surgery, Shinshu University School of Medicine
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Horiuchi A
Department of Gastroenterology, Showa Inan General Hospital
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Komatsu Michiharu
Department of Gastroenterology, Shinshu University School of Medicine
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