Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism

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• Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism : Hisao NAITO, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-Peroxisome proliferator-activated receptor a (PPAR α) plays a pivotal role in lipid metabolism. Our previous study reported that PPARA-V227A was a major polymorphism in Japanese, which was associated with markedly lower serum total cholesterol (TC) levels, which were significantly affected by alcohol drinking compared to subjects with the wild-type (PPARA-WT) allele. However, serum lipids are also associated with aging and exercise frequency. The objective of the present study was to evaluate the relationship between PPARA-V227A and these factors. Genetic analysis of the polymorphism was performed in 1058 Japanese men and 281 women, and the relationship with aging, drinking and exercise on serum lipids was analyzed in 989 men and 245 women after exclusion criteria had been applied. In men, drinking increased high-density lipoprotein cholesterol (HDL-C) levels in both PPARA-WT and A227 carriers, but to a significantly higher degree in the latter. In women, TC and low-density lipoprotein cholesterol (LDL-C) levels in the A227 carriers drinking at least once a week were significantly higher than in PPARA-WT carriers. TC and LDL-C levels in males with PPARA-WT increased with agingregardless of drinking habit, while LDL-C levels in the A227 drinking carriers were significantly lower in 45-yr-old or older subjects than in 35- to 45-yr-olds. In addition, no effect of exercising was observed in the A227 carriers, while increase in the HDL-C of the PPARA-WT carriers was exercise frequency dependent. These results suggest that the influence of drinking, aging or exercise on TC, LDL-C and HDL-C levels in the A227 carriers may be different from those in the PPARA-WT subiects.

• 社団法人日本産業衛生学会の論文

著者

• KAMIJIMA Michihiro

  Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medic

• KATOH Takahiko

  Department of Public Health, Faculty of Life Sciences, Kumamoto University

• 上島 通浩

  名古屋大学 衛生

• YAMANOSHITA OSAMU

  Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

• NAKAJIMA TAMIE

  Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

• AOYAMA Toshifumi

  Department of Metabolic Regulation, Institute of Aging and Adaptation, Shinshu University Graduate S

• GONZALEZ Frank

  Laboratory of Metabolism, National Cancer Institute, National Institutes of Health

• Kamijima Michihiro

  Department Of Occupational And Environmental Health Nagoya City University Graduate School Of Medica

• Kamijima Michihiro

  名古屋大学 医学部保健学科検査技術科学専攻

• Nakajima Tamie

  Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine

• Nakajima Tamie

  名古屋大学 大学院医学研究科

• Nakajima Tamie

  名古屋大学 医学系研究科環境労働衛生学

• Nakajima Tamie

  信州大学 医学部社会予防医学

• Kida M

  Nagoya City Univ. Graduate School Of Medical Sci.

• Yamanoshita Osamu

  Unit Of Environmental Health Sciences Department Of Biomedical Sciences College Of Life And Health S

• Yamanoshita Osamu

  信州大学 医学部社会予防医学

• Yamanoshita Osamu

  名古屋大学 医学系研究科環境労働衛生学

• Yamanoshita Osamu

  名古屋大学 医学研究科 環境労働衛生学

• Yamanoshita Osamu

  Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine

• Kamijima Michihiro

  Department Of Occupational And Environmental Health Nagoya University Of Graduate School Of Medicine

• Kadowaki Takashi

  滋賀大学 医学部健康科学科

• Tanaka Naoki

  Department of Gastroenterology, Shinshu University School of Medicine

• NAITO Hisao

  Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine

• Hisanaga N

  National Inst. Industrial Health Kawasaki Jpn

• Hisanaga Naomi

  労働安全衛生総合研究所

• Naito Hisao

  Dep. Of Occupational And Environmental Health Nagoya Univ. Graduate School Of Medicine

• Tamakoshi A

  Department Of Health Science Shiga University Of Medical Science

• 上島 通浩

  Dep. Of Occupational And Environmental Health Nagoya City Univ. Graduate School Of Medical Sci.

• Gonzalez Frank

  信州大学 医学部社会予防医学

• NAKAHARA Ai

  Department of Public Health, Miyazaki Medical College, University of Miyazaki

• Nakahara Ai

  Department Of Public Health Miyazaki Medical College University Of Miyazaki

• HISANAGA Naomi

  Aichi University of Education

• Katoh Takahiko

  Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health

• Kawase Takakazu

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Takemiya Kiyoko

  Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med

• Gonzalez Frank

  Laboratory Of Metabolism Division Of Basic Science National Cancer Institute

• Naito Hisao

  Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine

• Nakajima Tamie

  Department Of Hygiene School Of Medicine Shinshu University

• Aoyama Toshifumi

  Department Of Metabolic Regulation Institute Of Aging And Adaptation Shinshu University Graduate Sch

• Aoyama Toshifumi

  Department Of Biochemistry Shinshu University

• Kuzuya T

  Department Of Hospital Pharmacy Nagoya University School Of Medicine

• Tanaka Naoki

  Department Of Electronical And Computer Engineering Kumamoto University

• Tanaka Naoki

  Department Of Bio-molecular Engineering Kyoto Institute Of Technology

• Tanaka Naoki

  Department Of Metabolic Regulation Institute On Aging And Adaptation Shinshu University Graduate Sch

• Kamijima Michihiro

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

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