Human Herpesvirus 6 Reactivation in Trichloroethylene-exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction
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概要
- 論文の詳細を見る
Idiosyncratic generalized skin disorders resembling serious drug hypersensitivities have reportedly occurred after occupational exposure to trichloroethylene. However, factors associated with the disorders remain unknown except for trichloroethylene exposure. This study aimed at clarifying whether infectious diseases contributed to the development of rash or hepatitis in patients with trichloroethylene-related generalized skin disorders. Fifty-nine patients consecutively hospitalized between March 2002 and December 2003 and 59 healthy exposed workers selected on an age-matched basis in the patients' factories were enrolled in the study. Information on possible risk factors for rash and hepatitis was collected with structured checklists. Antibody titers were measured for hepatitis A, B and C viruses, Mycoplasma pneumoniae, herpes simplex viruses 1 and 2, Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, measles and rubella virus. Thirty-six cases (59%) showed exfoliative dermatitis, 17 (28%) erythema multiforme, 4 (7%) Stevens-Johnson syndrome, and 4 (7%) toxic epidermal necrolysis. Before the onset of rash, 16 (27%) cases had received medication prescribed for the preceding fever, a main first symptom of the disorders. Marked increases in anti-human herpesvirus 6 IgG titer (≥256), which indicated viral reactivation, were noted in 14 (25%) patients, while no abnormal increase was detected in the controls (p<0.001). Anti-measles IgM titer was positive in 2 (7%) cases but not in the controls (p=0.49). The involvement of other known risk factors of rash or hepatitis was ruled out. These results suggest that part of trichloroethylene-related generalized cutaneous disorders occurring in China and drug-induced hypersensitivity syndrome overlap in terms of human herpesvirus 6 reactivation.
- 社団法人日本産業衛生学会の論文
著者
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KAMIJIMA Michihiro
Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medic
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上島 通浩
名古屋大学 衛生
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NAKAJIMA TAMIE
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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TAKEUCHI Yasuhiro
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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Kamijima Michihiro
Department Of Occupational And Environmental Health Nagoya City University Graduate School Of Medica
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Kamijima Michihiro
名古屋大学 医学部保健学科検査技術科学専攻
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YOSHIKAWA Tetsushi
Department of Pediatrics, Fujita Health University School of Medicine
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Nakajima Tamie
Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine
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Nakajima Tamie
名古屋大学 大学院医学研究科
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Nakajima Tamie
名古屋大学 医学系研究科環境労働衛生学
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Nakajima Tamie
信州大学 医学部社会予防医学
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Takeuchi Y
Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine
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Yoshikawa Tetsushi
Department Of Pediatrics Fujita Health University School Of Medicine
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Wang Hailan
Guangdong Poison Control Center
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Wang Hailan
Hospital For Occupational Diseases Control Of Guangdong Province
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Wang Hailan
名古屋大学 医学系研究科環境労働衛生学
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Wang Hailan
中華人民共和国
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Wang Hailan
Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine
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上島 通浩
Dep. Of Occupational And Environmental Health Nagoya City Univ. Graduate School Of Medical Sci.
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HUANG Hanlin
Hospital for Occupational Diseases Control of Guangdong Province
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LI Laiyu
Hospital for Occupational Diseases Control of Guangdong Province
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LIU Huifang
Hospital for Occupational Diseases Control of Guangdong Province
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CHEN Jiabin
Hospital for Occupational Diseases Control of Guangdong Province
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HUANG Zhenlie
Hospital for Occupational Diseases Control of Guangdong Province
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LI Senhua
Guangdong Poison Control Center
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HUANG Hanlin
Guangdong Poison Control Center
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LI Laiyu
Guangdong Poison Control Center
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LI Senhua
Hospital for Occupational Diseases Control of Guangdong Province
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LAI Guanchao
Hospital for Occupational Diseases Control of Guangdong Province
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Takeuchi Yasuhiro
Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine
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Nakajima Tamie
Department Of Hygiene School Of Medicine Shinshu University
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Takeuchi Yasuhiro
Department Of Applied Mathematics Faculty Of Engineering Shizuoka University
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Kamijima Michihiro
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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