Changes in Cholinesterase Activity, Nerve Conduction Velocity, and Clinical Signs and Symptoms in Termite Control Operators Exposed to Chlorpyrifos

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We have surveyed periodical medical examinations for pest and termite control operators (n=64) exposed to chlorpyrifos and other organophosphate pesticides. Distribution of serum butyrycholinesterase (BuChE) activities of all workers ranged 0.01-1.18(ΔpH). Serum BuChE activities in 6 workers in one termite control company were severely depressed and ranged from 0.01 to 0.21 ΔpH. Erythrocyte acetylcholinesterase (AChE) activities in 3 workers were lower than the normal range. Erythrocyte AChE activities and serum BuChE acitivities in chlorpyrifos sprayers were significantly correlated (r=0.720). In other clinical signs, blood urine nitrogen (BUN) in 4 workers and white blood cell (WBC) counts in 4 workers were abnormal. Sensory nerve conduction velocities in the sural nerve of all 6 workers were significantly reduced to 18.8-26.6 m/s in the left leg and 19.2-27.2 m/s in the right leg. In the results of ophthalmic examinations, accommodation time (both eyes) in 4 workers extended over the normal range and electroretinography (ERG) in 2 workers showed abnormal ERG including disappearance of oscillatory potential. Chlorpyrifos residue in blood in 4 operators whose serum BuChE activities ranged from 0.01 to 0.03 ΔpH were detected in the range 2-8 ng/ml. They had sprayed chlorpyrifos daily for 5 d before every blood sampling, It is suggested that serum BuChE activity and sensory nerve conduction velocity are sensitive indicators to evaluate the effects of chlorpyrifos exposure, and may be used effectively to monitor exposure and the effects of chlorpyrifos on health.
社団法人日本産業衛生学会の論文

Changes in Cholinesterase Activity, Nerve Conduction Velocity, and Clinical Signs and Symptoms in Termite Control Operators Exposed to Chlorpyrifos

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