Effects of Phenyl Derivatives of Dihydropyrazines with Ability to Generate Radical Species on Escherichia coli(Biochemistry)
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概要
- 論文の詳細を見る
Phenyl-substituted dihydropyrazines (Ph-DHPs) are derivatives of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP). Upon the addition of Cu^<2+>, Me-DHP inhibits the growth of Escherichia coli by generating hydroxyl and carbon-centered radicals that cause DNA strand breakage. Here, we investigated the toxic effect of Ph-DHPs in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains. Ph-DHPs caused cytotoxic and genotoxic damage, but, in a sodA sodB strain, the effects in the presence or absence of Cu^<2+> were different than those of Me-DHP. Our results suggest that the action of the generated superoxide anion in the interior side of the cell is remarkable.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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OMORI Hisamitsu
Department of Public Health, Faculty of Life Sciences, Kumamoto University
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KATOH Takahiko
Department of Public Health, Faculty of Life Sciences, Kumamoto University
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Katoh Takahiko
Dep. Of Public Health Fac. Of Life Sciences Kumamoto Univ.
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Katoh Takahiko
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Omori Hisamitsu
Dep. Of Public Health Fac. Of Life Sciences Kumamoto Univ.
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TAKEDA Osamu
Department of Public Health, Faculty of Medicine, University of Miyazaki
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TAKECHI Shinji
Faculty of Pharmaceutical Sciences, Sojo University
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ITO Shigeru
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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OMORI Hisamitsu
Kumamoto Health Center, Japanese Red Cross
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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Yamaguchi Tokio
Faculty Of Pharmaceutical Sciences Sojo University
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Ito S
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Takeda Osamu
Department Of Public Health Faculty Of Medicine University Of Miyazaki
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Takeda Shuso
Graduate School Of Pharmaceutical Sciences Kyushu University
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Takechi Shinji
Dept. Biochem. Miyazaki Med. Coll.
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Omori Hisamitsu
Kumamoto Health Center Japanese Red Cross
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Takechi Shinji
Faculty Of Pharmaceutical Sciences Sojo University
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Tadatoshi Yamaguchi
Faculty Of Hygiene Miyazaki Medical College
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Yamaguchi Tadatoshi
Faculty Of Pharmaceutical Sciences Sojo University
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Ito Shigeru
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Takechi Shinji
Faculty of Pharmaceutical Science, Sojo University
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Yamaguchi Tadatoshi
Faculty of Pharmaceutical Science, Sojo University
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Takeda Osamu
Department of Materials Science and Technology, Faculty of Engineering, Niigata University
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